Methyl 6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylate | CAS No. 872355-54-9

Methyl 6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylate

Basic Information

CAS Number

872355-54-9

Molecular Formula

C10H10N2O2

Molecular Weight

190.2 g/mol

AD

Basic Physical Properties

O=C(C1=C(C)N=C(NC=C2)C2=C1)OC

InChI

InChI=1S/C10H10N2O2/c1-6-8(10(13)14-2)5-7-3-4-11-9(7)12-6/h3-5H,1-2H3,(H,11,12)

InChIKey

LHAHLXKZWRIQNR-UHFFFAOYSA-N

LogP

1.6579199999999998

Topological Polar Surface Area

54.980000000000004 Ų

Hydrogen Bond Donor/Acceptor

1 / 4

Synonyms & References

English

  • Methyl 6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylate
  • 1H-Pyrrolo[2,3-b]pyridine-5-carboxylic acid, 6-methyl-, methyl ester
  • 6-Methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid methyl ester
  • Methyl 6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylate (ACI)

MDL Number

MFCD14706594

FAQ

What are the physical and chemical properties of Methyl 6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylate (CAS: 872355-54-9)?

Methyl 6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylate (CAS: 872355-54-9) is a white crystalline solid with a molecular weight of approximately 221.25 g/mol. It has a low solubility in water but is soluble in common organic solvents like methanol, ethanol, and acetonitrile. The compound is relatively stable under normal conditions but may react with strong acids or bases. It is used in the synthesis of various chemical intermediates and pharmaceuticals.

How is Methyl 6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylate (CAS: 872355-54-9) typically synthesized?

Methyl 6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylate (CAS: 872355-54-9) is typically synthesized via a multistep process starting from 6-methyl-1H-pyrrolo[2,3-b]pyridine. The synthesis involves the esterification of the pyridine ring with methyl alcohol under acidic conditions. The reaction is carried out with a good yield and selectivity, yielding the desired compound.

What industries use Methyl 6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylate (CAS: 872355-54-9)?

Methyl 6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylate (CAS: 872355-54-9) is primarily used in the pharmaceutical industry as a precursor for the synthesis of active pharmaceutical ingredients (APIs). It also finds applications in the synthesis of certain dyes and pigments, as a chemical intermediate.

What precautions should be taken when handling Methyl 6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylate (CAS: 872355-54-9)?

When handling Methyl 6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylate (CAS: 872355-54-9), it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. It should be stored in a cool, dry place, away from strong acids, bases, and oxidizing agents. Spills should be handled with care, and the area should be cleaned up immediately. Always refer to the safety data sheet (SDS) for detailed handling and disposal information.

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