2-(Hydroxymethyl)phenylboronic acid

Basic Information

View in Editor

CAS Number

87199-14-2

Molecular Formula

C7H9BO3

Molecular Weight

151.96 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Hydrocarbons

Basic Physical Properties

Physical State

No data available

Melting Point

No data available

Boiling Point

379.8℃ at 760 mmHg

Density

1.25

Water Solubility

Slightly soluble in water.

Flash Point

183.5℃

Refractive Index

1.566

SMILES

View in Editor

B(C1=CC=CC=C1CO)(O)O

InChI

InChI=1S/C7H9BO3/c9-5-6-3-1-2-4-7(6)8(10)11/h1-4,9-11H,5H2

InChIKey

AFHOBSCDNXGFMO-UHFFFAOYSA-N

LogP

-1.1413000000000002

Topological Polar Surface Area

60.69 Å²

Hydrogen Bond Donor/Acceptor

3 / 3

Complexity

118

Safety Information

View Safety Information

GHS Hazard Pictograms

H315

H319

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

(2-(Hydroxymethyl)phenyl)boronic acid
(2-Hydroxymethylphenyl)boronic acid dehydrate
2-(Hydroxymethyl)benzeneboronic acid
2-(Hydroxymethyl)phenylboronic Acid (contains varying amounts of Anhydride)
(2-hydroxymethylphenyl)boronic acid
[2-(hydroxymethyl)phenyl]boronic acid
2-(HYDROXYMETHYL)PHENYLBORONIC ACID
2-Hydroxymethylphenylboronic acid
o-(Hydroxymethyl)phenylboronic Acid
2-(Hydroxymethyl)benzeneboronic Acid (contains varying amounts of Anhydride)
Boronic acid, [2-(hydroxymethyl)phenyl]-
KSC489M2P
o-hydroxymethyl phenylboronic acid
AFHOBSCDNXGFMO-UHFFFAOYSA-N
2-hydroxymethyl-phenylboronic acid
2-Hydroxymethylphenyl)boronic acid
2-(Hydroxymethyl)phenylboranic acid
ZX-AT0
2-(Hydroxymethyl)phenylboronic acid
(2-(hydroxymethyl)phenyl)boronic acid
MFCD02258966
[2-(hydroxymethyl)phenyl]boronic Acid
CS-W000996
DTXSID20402562
o-(hydroxymethyl)phenylboronic acid
GS-6630
SY014964
J-506438
H1345
(2-(Hydroxymethyl)phenyl)boronicacid
AKOS000285067

MDL Number

MFCD02258966

Customs Code

2931900090

FAQ

What are the physical and chemical properties of 2-(Hydroxymethyl)phenylboronic acid (CAS: 87199-14-2)?

2-(Hydroxymethyl)phenylboronic acid has a crystalline form and a molecular weight of approximately 217.12 g/mol. It is slightly soluble in water and organic solvents. This compound exhibits good reactivity in boronate ester formation and undergoes reactions in the presence of a palladium catalyst, showing high selectivity and yield in Suzuki coupling reactions.

How is 2-(Hydroxymethyl)phenylboronic acid (CAS: 87199-14-2) typically synthesized?

2-(Hydroxymethyl)phenylboronic acid is commonly synthesized via the Stille coupling reaction, where phenylboronic acid reacts with bromo or iodo derivatives of 2-hydroxymethylbenzene in the presence of a palladium catalyst and a base. This method provides high yield and selectivity, making it a preferred synthetic route for this compound.

What industries use 2-(Hydroxymethyl)phenylboronic acid (CAS: 87199-14-2)?

2-(Hydroxymethyl)phenylboronic acid is widely used in the pharmaceutical industry for the synthesis of drug intermediates, in the polymer industry for the modification of polymers, and in the semiconductor industry for the fabrication of boron-doped materials. It also has applications in sensors and other advanced materials.

What precautions should be taken when handling 2-(Hydroxymethyl)phenylboronic acid (CAS: 87199-14-2)?

When handling 2-(Hydroxymethyl)phenylboronic acid, proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. It should be stored in a cool, dry place away from direct sunlight and other oxidizing agents. In case of spill, immediately clean up using appropriate absorbents and follow the safety data sheet (SDS) for disposal instructions.