2-(Hydroxymethyl)phenylboronic acid(CAS: 87199-14-2)

2-(Hydroxymethyl)phenylboronic acid has a crystalline form and a molecular weight of approximately 217.12 g/mol. It is slightly soluble in water and organic solvents. This compound exhibits good reactivity in boronate ester formation and undergoes reactions in the presence of a palladium catalyst, showing high selectivity and yield in Suzuki coupling reactions.

2-(Hydroxymethyl)phenylboronic acid is commonly synthesized via the Stille coupling reaction, where phenylboronic acid reacts with bromo or iodo derivatives of 2-hydroxymethylbenzene in the presence of a palladium catalyst and a base. This method provides high yield and selectivity, making it a preferred synthetic route for this compound.

2-(Hydroxymethyl)phenylboronic acid is widely used in the pharmaceutical industry for the synthesis of drug intermediates, in the polymer industry for the modification of polymers, and in the semiconductor industry for the fabrication of boron-doped materials. It also has applications in sensors and other advanced materials.

When handling 2-(Hydroxymethyl)phenylboronic acid, proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. It should be stored in a cool, dry place away from direct sunlight and other oxidizing agents. In case of spill, immediately clean up using appropriate absorbents and follow the safety data sheet (SDS) for disposal instructions.