(2-Fluoro-6-iodophenyl)boronic acid

Basic Information

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CAS Number

870777-22-3

Molecular Formula

C6H5BFIO2

Molecular Weight

265.82 g/mol

Chemical Classification

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

135-139 °C

Boiling Point

338.3°C at 760 mmHg

Density

2.01

Flash Point

158.4°C

Refractive Index

1.621

SMILES

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IC1=C(B(O)O)C(F)=CC=C1

InChI

InChI=1S/C6H5BFIO2/c8-4-2-1-3-5(9)6(4)7(10)11/h1-3,10-11H

InChIKey

LBSXGVJFWVWITH-UHFFFAOYSA-N

LogP

0.11009999999999998

Topological Polar Surface Area

40.46 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Synonyms & References

English

(2-Fluoro-6-iodophenyl)boronic acid
2-Fluoro-6-iodophenylboronic acid
Boronic acid,B-(2-fluoro-6-iodophenyl)-

MDL Number

MFCD06798080

Customs Code

2931900090

FAQ

What are the physical and chemical properties of (2-Fluoro-6-iodophenyl)boronic acid (CAS: 870777-22-3)?

(2-Fluoro-6-iodophenyl)boronic acid is a crystalline compound with a molecular weight of approximately 345.07 g/mol. It has low water solubility and moderate solubility in organic solvents such as ethanol and acetone. This compound shows high reactivity in boronate ester formation and is commonly used in organic synthesis for its stabilizing effects on boronic acids.

How is (2-Fluoro-6-iodophenyl)boronic acid (CAS: 870777-22-3) typically synthesized?

(2-Fluoro-6-iodophenyl)boronic acid can be synthesized using a fluoroiodophenol as a starting material, followed by a boronic acid coupling reaction. Common methods involve the use of palladium catalysts and base, with good selectivity and yield. The reaction typically occurs in the presence of anhydrous conditions to avoid decomposition.

What industries use (2-Fluoro-6-iodophenyl)boronic acid (CAS: 870777-22-3)?

(2-Fluoro-6-iodophenyl)boronic acid finds applications in pharmaceuticals for drug synthesis, in polymers for functionalization, and in sensors for reactivity testing. It is also utilized in semiconductor manufacturing for its unique chemical properties, making it a versatile compound across various industries.

What precautions should be taken when handling (2-Fluoro-6-iodophenyl)boronic acid (CAS: 870777-22-3)?

When handling (2-Fluoro-6-iodophenyl)boronic acid, it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be stored in a fume hood to minimize exposure. In case of a spill, it should be handled using appropriate cleanup procedures and materials. Always consult a safety data sheet (SDS) for detailed handling and disposal instructions.