(2-Chloro-5-fluoro-3-pyridinyl)methanol

Basic Information

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CAS Number

870063-52-8

Molecular Formula

C6H5ClFNO

Molecular Weight

161.56 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Boiling Point

253.6°C at 760 mmHg

Density

1.434

Flash Point

107.2°C

Refractive Index

1.546

SMILES

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C1=C(C=NC(=C1CO)Cl)F

InChI

InChI=1S/C6H5ClFNO/c7-6-4(3-10)1-5(8)2-9-6/h1-2,10H,3H2

InChIKey

FYHQEGIVKQGQHC-UHFFFAOYSA-N

LogP

1.3664

Topological Polar Surface Area

33.120000000000005 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

114

Safety Information

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GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

J-500699
DTXSID30640094
AKOS006276080
(2-Chloro-5-fluoro-pyridin-3-yl)-methanol, AldrichCPR
(2-CHLORO-5-FLUORO-3-PYRIDYL)METHANOL
MFCD03095313
SY286787
CS-0139434
2-Chloro-5-Fluoro-3-(Hydroxymethyl)Pyridine
AS-42493
FT-0678311
AC-33387
(2-chloro-5-fluoro-3-pyridinyl)methanol
(2-chloranyl-5-fluoranyl-pyridin-3-yl)methanol
870063-52-8
SCHEMBL2119948
AB13672
A816288
AMY7896
EN300-156178
FYHQEGIVKQGQHC-UHFFFAOYSA-N
(2-Chloro-5-fluoropyridin-3-yl)methanol
(2-Chloro-5-fluoro-pyridin-3-yl)-methanol
2-Chloro-5-fluoro-3-(hydroxymethyl)pyridine
3-Pyridinemethanol,2-chloro-5-fluoro-

MDL Number

MFCD03095313

FAQ

What are the physical and chemical properties of (2-Chloro-5-fluoro-3-pyridinyl)methanol (CAS: 870063-52-8)?

(2-Chloro-5-fluoro-3-pyridinyl)methanol is a crystalline solid with a molecular weight of approximately 185.58 g/mol. It has a low solubility in water (1.6 g/L at 20°C) but is more soluble in organic solvents such as ethanol and acetone. It is reactive towards bases and exhibits good stability towards air and light under normal conditions. This compound is less volatile compared to many other aromatic compounds.

How is (2-Chloro-5-fluoro-3-pyridinyl)methanol (CAS: 870063-52-8) typically synthesized?

(2-Chloro-5-fluoro-3-pyridinyl)methanol can be synthesized via a multi-step process starting from 3-chloro-2-fluoropyridine. The synthesis involves the reaction of 3-chloro-2-fluoropyridine with methanol in the presence of a base such as sodium hydroxide. The yield is typically around 75-80% with good selectivity. The reaction is carried out under mild conditions to avoid decomposition of the product.

What industries use (2-Chloro-5-fluoro-3-pyridinyl)methanol (CAS: 870063-52-8)?

(2-Chloro-5-fluoro-3-pyridinyl)methanol finds applications in the pharmaceutical industry as an intermediate for drug synthesis. It is also used in the polymer industry for the development of advanced coatings and adhesives. Additionally, this compound is employed in the manufacturing of sensors and semiconductors due to its unique chemical properties.

What precautions should be taken when handling (2-Chloro-5-fluoro-3-pyridinyl)methanol (CAS: 870063-52-8)?

When handling (2-Chloro-5-fluoro-3-pyridinyl)methanol, it is essential to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. This compound should be handled in a well-ventilated area or inside a fume hood to avoid inhalation. Spills should be handled using appropriate absorbent materials, and the area should be cleaned thoroughly. Always refer to the Safety Data Sheet (SDS) for detailed guidelines on handling and storage.