Compound Q&A

How is (2-Chloro-5-fluoro-3-pyridinyl)methanol (CAS: 870063-52-8) typically synthesized?

Answer

(2-Chloro-5-fluoro-3-pyridinyl)methanol
(2-Chloro-5-fluoro-3-pyridinyl)methanol can be synthesized via a multi-step process starting from 3-chloro-2-fluoropyridine. The synthesis involves the reaction of 3-chloro-2-fluoropyridine with methanol in the presence of a base such as sodium hydroxide. The yield is typically around 75-80% with good selectivity. The reaction is carried out under mild conditions to avoid decomposition of the product.

About

English Name (2-Chloro-5-fluoro-3-pyridinyl)methanol
Molecular Formula C6H5ClFNO
Molecular Weight 161.56 g/mol
SMILES C1=C(C=NC(=C1CO)Cl)F
InChIKey FYHQEGIVKQGQHC-UHFFFAOYSA-N
Last Updated: 2025-11-27 19:31

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