(2-Chloro-5-fluoro-3-pyridinyl)methanol(CAS: 870063-52-8)

(2-Chloro-5-fluoro-3-pyridinyl)methanol is a crystalline solid with a molecular weight of approximately 185.58 g/mol. It has a low solubility in water (1.6 g/L at 20°C) but is more soluble in organic solvents such as ethanol and acetone. It is reactive towards bases and exhibits good stability towards air and light under normal conditions. This compound is less volatile compared to many other aromatic compounds.

(2-Chloro-5-fluoro-3-pyridinyl)methanol can be synthesized via a multi-step process starting from 3-chloro-2-fluoropyridine. The synthesis involves the reaction of 3-chloro-2-fluoropyridine with methanol in the presence of a base such as sodium hydroxide. The yield is typically around 75-80% with good selectivity. The reaction is carried out under mild conditions to avoid decomposition of the product.

(2-Chloro-5-fluoro-3-pyridinyl)methanol finds applications in the pharmaceutical industry as an intermediate for drug synthesis. It is also used in the polymer industry for the development of advanced coatings and adhesives. Additionally, this compound is employed in the manufacturing of sensors and semiconductors due to its unique chemical properties.

When handling (2-Chloro-5-fluoro-3-pyridinyl)methanol, it is essential to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. This compound should be handled in a well-ventilated area or inside a fume hood to avoid inhalation. Spills should be handled using appropriate absorbent materials, and the area should be cleaned thoroughly. Always refer to the Safety Data Sheet (SDS) for detailed guidelines on handling and storage.