1-(3-Chloro-2-pyrazinyl)methanamine dihydrochloride

Basic Information

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CAS Number

867165-53-5

Molecular Formula

C5H8Cl3N3

Molecular Weight

216.5 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

SMILES

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NCC1=NC=CN=C1Cl.[H]Cl.[H]Cl

InChI

InChI=1S/C5H6ClN3.2ClH/c6-5-4(3-7)8-1-2-9-5;;/h1-2H,3,7H2;2*1H

InChIKey

RHKWGVWUXBFIIE-UHFFFAOYSA-N

LogP

1.4323

Topological Polar Surface Area

51.8 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

(3-Chloropyrazin-2-yl)methanamine dihydrochloride
3-Chloropyrazin-2-methanaminedihydrochloride
(3-Chloropyrazin-2-yl)-methanamine HCl
(3-chloropyrazin-2-yl)methanamine hydrochloride
(3-Chloropyrazine-2-yl)MethanaMine dihydrochloride
(3-chloropyrazin-2-yl)methanamine dihydrochloride

MDL Number

MFCD07644629

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 1-(3-Chloro-2-pyrazinyl)methanamine dihydrochloride (CAS: 867165-53-5)?

1-(3-Chloro-2-pyrazinyl)methanamine dihydrochloride is a crystalline compound with a molecular weight of approximately 254.04 g/mol. It has a high solubility in water and is sparingly soluble in organic solvents. The compound is moderately reactive, particularly towards nucleophiles. It exists as dihydrochloride salt, which enhances its stability and solubility properties.

How is 1-(3-Chloro-2-pyrazinyl)methanamine dihydrochloride (CAS: 867165-53-5) typically synthesized?

1-(3-Chloro-2-pyrazinyl)methanamine dihydrochloride is typically synthesized via a multi-step process involving the reaction of 3-chloro-2-pyrazinecarbothioic acid methyl ester with methylamine followed by HCl addition to form the dihydrochloride salt. The synthesis involves careful control of pH and temperature to enhance selectivity and yield.

What industries use 1-(3-Chloro-2-pyrazinyl)methanamine dihydrochloride (CAS: 867165-53-5)?

1-(3-Chloro-2-pyrazinyl)methanamine dihydrochloride is used in the pharmaceutical industry for its potential as an intermediate in drug synthesis. It may also find applications in the polymer industry, where it can be incorporated as a functional monomer. Additionally, it has potential uses in the development of sensors and semiconductors due to its chemical functionality.

What precautions should be taken when handling 1-(3-Chloro-2-pyrazinyl)methanamine dihydrochloride (CAS: 867165-53-5)?

When handling 1-(3-Chloro-2-pyrazinyl)methanamine dihydrochloride, it is essential to use personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate absorbents. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information and emergency procedures.