Fmoc-NH-PEG3-CH2CH2COOH

Basic Information

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CAS Number

867062-95-1

Molecular Formula

C24H29NO7

Molecular Weight

443.5 g/mol

Basic Physical Properties

Boiling Point

651.1°C at 760 mmHg

Density

1.230

Flash Point

347.588°C

Refractive Index

1.571

SMILES

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OC(=O)CCOCCOCCOCCNC(=O)OCC1c2ccccc2-c3ccccc13

InChI

InChI=1S/C24H29NO7/c26-23(27)9-11-29-13-15-31-16-14-30-12-10-25-24(28)32-17-22-20-7-3-1-5-18(20)19-6-2-4-8-21(19)22/h1-8,22H,9-17H2,(H,25,28)(H,26,27)

InChIKey

CHIDDYZONKDHLG-UHFFFAOYSA-N

LogP

3.0496000000000025

Topological Polar Surface Area

103.32000000000001 Å²

Hydrogen Bond Donor/Acceptor

2 / 8

Complexity

551

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13-tetraoxa-4-azahexadecan-16-oic acid
FMoc-NH-PEG3-CH2CH2COOH
5,8,11-Trioxa-2-azatetradecanedioicacid, 1-(9H-fluoren-9-ylmethyl) ester
Fmoc-12-amino-4,7,10-trioxadodecanoic acid
2-[2-[2-(2-aminoethoxy)ethoxy]ethoxymethyl]-3-(9H-fluoren-9-ylmethoxy)-3-oxopropanoic acid
Fmoc-PEG3-propionic acid
Fmoc-N-amido-PEG3-acid
AK128308
C24H29NO7
5,8,11-Trioxa-2-azatetradecanedioic acid, 1-(9H-fluoren-9-ylmethyl) ester
3-[2-[2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]ethoxy]propanoic Acid
FmocNH-PEG3-CH2CH2COOH
BIPG1397
BCP20517
Fm
Fmoc-NH-PEG3-CH2CH2COOH

MDL Number

MFCD06656471

Customs Code

2934999090

FAQ

What are the physical and chemical properties of Fmoc-NH-PEG3-CH2CH2COOH (CAS: 867062-95-1)?

Fmoc-NH-PEG3-CH2CH2COOH is a solid compound with a molecular weight of approximately 450.5 g/mol. It has poor water solubility but good solubility in organic solvents like DMSO. This compound is highly reactive, particularly towards carboxylic acids and amine groups. It is commonly used in solid-phase peptide synthesis and as a linker in polymer chemistry.

How is Fmoc-NH-PEG3-CH2CH2COOH (CAS: 867062-95-1) typically synthesized?

Fmoc-NH-PEG3-CH2CH2COOH is synthesized via a multi-step process involving the coupling of an amino acid to polyethylene glycol (PEG) using a coupling reagent like N-hydroxysuccinimide (NHS) and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC). The reaction is typically carried out in a polar aprotic solvent like N,N-Dimethylformamide (DMF) at room temperature or slightly elevated temperatures. The yield is generally high, with selectivity towards the amine coupling.

What industries use Fmoc-NH-PEG3-CH2CH2COOH (CAS: 867062-95-1)?

Fmoc-NH-PEG3-CH2CH2COOH is widely used in the pharmaceutical industry for the synthesis of peptides and proteins. It is also utilized in polymer chemistry to create functional polymers, in sensor technology for biomolecule detection, and in semiconductor industry for surface modification applications.

What precautions should be taken when handling Fmoc-NH-PEG3-CH2CH2COOH (CAS: 867062-95-1)?

When handling Fmoc-NH-PEG3-CH2CH2COOH, it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated fume hood. Spills should be cleaned up using appropriate absorbent materials. In case of contact with skin or eyes, flush with water and seek medical advice. Always refer to the Safety Data Sheet (SDS) for detailed safety information.