Fmoc-NH-PEG3-CH2CH2COOH(CAS: 867062-95-1)

Fmoc-NH-PEG3-CH2CH2COOH is a solid compound with a molecular weight of approximately 450.5 g/mol. It has poor water solubility but good solubility in organic solvents like DMSO. This compound is highly reactive, particularly towards carboxylic acids and amine groups. It is commonly used in solid-phase peptide synthesis and as a linker in polymer chemistry.

Fmoc-NH-PEG3-CH2CH2COOH is synthesized via a multi-step process involving the coupling of an amino acid to polyethylene glycol (PEG) using a coupling reagent like N-hydroxysuccinimide (NHS) and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC). The reaction is typically carried out in a polar aprotic solvent like N,N-Dimethylformamide (DMF) at room temperature or slightly elevated temperatures. The yield is generally high, with selectivity towards the amine coupling.

Fmoc-NH-PEG3-CH2CH2COOH is widely used in the pharmaceutical industry for the synthesis of peptides and proteins. It is also utilized in polymer chemistry to create functional polymers, in sensor technology for biomolecule detection, and in semiconductor industry for surface modification applications.

When handling Fmoc-NH-PEG3-CH2CH2COOH, it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated fume hood. Spills should be cleaned up using appropriate absorbent materials. In case of contact with skin or eyes, flush with water and seek medical advice. Always refer to the Safety Data Sheet (SDS) for detailed safety information.