Compound Q&A
How is Fmoc-NH-PEG3-CH2CH2COOH (CAS: 867062-95-1) typically synthesized?
Answer
Fmoc-NH-PEG3-CH2CH2COOH is synthesized via a multi-step process involving the coupling of an amino acid to polyethylene glycol (PEG) using a coupling reagent like N-hydroxysuccinimide (NHS) and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC). The reaction is typically carried out in a polar aprotic solvent like N,N-Dimethylformamide (DMF) at room temperature or slightly elevated temperatures. The yield is generally high, with selectivity towards the amine coupling.
About
CAS No
867062-95-1
English Name
Fmoc-NH-PEG3-CH2CH2COOH
Molecular Formula
C24H29NO7
Molecular Weight
443.5 g/mol
SMILES
OC(=O)CCOCCOCCOCCNC(=O)OCC1c2ccccc2-c3ccccc13
InChIKey
CHIDDYZONKDHLG-UHFFFAOYSA-N
Last Updated: 2025-10-05 08:54
