3-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

Basic Information

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CAS Number

865186-94-3

Molecular Formula

C11H15BClNO2

Molecular Weight

239.51 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

79.0 to 83.0 deg-C

Boiling Point

327.5°C at 760 mmHg

Density

1.14

Flash Point

151.9°C

Refractive Index

1.505

SMILES

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B1(OC(C(O1)(C)C)(C)C)c2cc(cnc2)Cl

InChI

InChI=1S/C11H15BClNO2/c1-10(2)11(3,4)16-12(15-10)8-5-9(13)7-14-6-8/h5-7H,1-4H3

InChIKey

WCKBNAJTZUVHPD-UHFFFAOYSA-N

LogP

2.0342

Topological Polar Surface Area

31.35 Å²

Hydrogen Bond Donor/Acceptor

0 / 3

Complexity

257

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

3-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
5-Chloropyridine-3-boronic acid pinacol ester
3-Chloro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine
Pyridine, 3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
2-(5-Chloro-3-pyridyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
5-Chloropyridine-3-boronic acid, pinacol ester
3-chloro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridine
3-chloro-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
3-chloranyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
PubChem21018
3-CHLOROPYRIDINE-5-BORONIC ACID PINACOL ESTER
SCH
5-Chloropyridine-3-boronic Acid Pinacol Ester
3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

MDL Number

MFCD06798284

Customs Code

2934999090

FAQ

What is 3-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (CAS: 865186-94-3)?

3-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is a pyridine derivative with a chloro and a tetramethyl-1,3,2-dioxaborolane substituent. It is a colorless liquid with a molecular weight of approximately 352.12 and a boiling point around 180°C. This compound is used in organic synthesis, particularly in boronate ester formation and as a boronic acid derivative in various chemical reactions.

What are the main uses of 3-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (CAS: 865186-94-3)?

3-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is primarily used in the pharmaceutical and chemical industries for the synthesis of organic compounds. It serves as a key reagent in cross-coupling reactions, particularly in the formation of C-C bonds. The compound is also used in the preparation of boronate esters and as a boronic acid derivative in various chemical processes.

Is 3-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (CAS: 865186-94-3) safe?

3-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is generally considered safe when handled with appropriate precautions. It is flammable and should be stored in a cool, dry place away from heat sources and direct sunlight. Protective gloves and goggles should be worn during handling to prevent skin and eye contact. Inhalation of vapors should be avoided, and appropriate ventilation is recommended.

How should 3-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (CAS: 865186-94-3) be stored?

3-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine should be stored in a tightly closed container in a cool, dry place. It should be kept away from heat sources, direct sunlight, and moisture. The storage temperature should not exceed 25°C, and the container should be protected from light. It is important to keep the compound away from incompatible materials such as oxidizers and ensure proper ventilation in the storage area.