2'-Deoxy-2'-fluoro-2'-methyluridine

Basic Information

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CAS Number

863329-66-2

Molecular Formula

C10H13FN2O5

Molecular Weight

260.22 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

237-238℃

Density

1.55

SMILES

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OC[C@H]1O[C@H]([C@]([C@@H]1O)(C)F)n1ccc(=O)[nH]c1=O

InChI

InChI=1S/C10H13FN2O5/c1-10(11)7(16)5(4-14)18-8(10)13-3-2-6(15)12-9(13)17/h2-3,5,7-8,14,16H,4H2,1H3,(H,12,15,17)/t5-,7-,8-,10-/m1/s1

InChIKey

ARKKGZQTGXJVKW-VPCXQMTMSA-N

LogP

-1.4846000000000001

Topological Polar Surface Area

104.54999999999998 Å²

Hydrogen Bond Donor/Acceptor

3 / 7

Complexity

415

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

(2'R)-2'-Deoxy-2'-fluoro-2'-methyl-uridine
(2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine
PSI-6206
RO 2433
Uridine, 2'-deoxy-2'-fluoro-2'-Methyl-, (2'R)-
Uridine, 2'-deoxy-2'-fluoro-2'-Methyl-, (2'R)- PSI6206
2'-Deoxy-2-floro-2'Methyl-uridine
1-((2S,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione
2'-deoxy-2'-fluoro-2'-C-methyluridine
1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyl-tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
1-((2R,3R,4R,5R)-3-FLUORO-4-HYDROXY-5-(HYDROXYMETHYL)-3-METHYLTETRAHYDROFURAN-2-YL)PYRIMIDINE-2,4(1H,3H)-DIONE
2-deoxy-2-fluoro-2-methyluridine
PSI6206
Sofosbuvir metabolites GS331007
β-D-2'-deoxy-2'-α-F-2'-β-C-methyluridine
β-D-2'-deoxy-2'-α-fluoro-2'C-methyluridine
2'-deoxy-2'-fluoro-2'-C-methyl-uridine
Ro-2433
URI002
44V7045CXS
2'-deoxy-2'-fluoro-2'-methyluridine
1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione
(2'R)-2'-Deoxy-2'-fluoro-2'-methyl-uri
GS-331007
1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

MDL Number

MFCD19982668

Customs Code

2934999090

FAQ

What is 2'-Deoxy-2'-fluoro-2'-methyluridine (CAS: 863329-66-2)?

2'-Deoxy-2'-fluoro-2'-methyluridine is a modified nucleoside with the chemical formula C10H13FN4O5. It features a fluorine and methyl group at the 2' position of the ribose ring, altering its properties compared to natural uridine. This compound is a white solid and exhibits solubility in polar solvents. Its structural modifications make it a key candidate for pharmaceutical and research applications, particularly in nucleic acid studies.

What are the main uses of 2'-Deoxy-2'-fluoro-2'-methyluridine (CAS: 863329-66-2)?

2'-Deoxy-2'-fluoro-2'-methyluridine is primarily used in pharmaceutical research as a nucleoside analog, with potential applications in antiviral and anticancer drug development. It is also employed in molecular biology studies to investigate RNA structure and function, and in biochemical assays to explore nucleic acid interactions. Its unique chemical properties make it valuable for synthetic chemistry and drug design.

Is 2'-Deoxy-2'-fluoro-2'-methyluridine (CAS: 863329-66-2) safe?

2'-Deoxy-2'-fluoro-2'-methyluridine is generally considered safe when handled properly, but it may cause mild irritation upon contact with skin or eyes. Safety data sheets (SDS) recommend using protective gloves, goggles, and ventilation. It is not classified as highly toxic, but standard laboratory safety protocols should be followed to minimize exposure risks.

How should 2'-Deoxy-2'-fluoro-2'-methyluridine (CAS: 863329-66-2) be stored?

Store 2'-Deoxy-2'-fluoro-2'-methyluridine in a sealed container at room temperature (15-25°C), away from moisture and light. Maintain low humidity conditions to prevent degradation. For long-term stability, refrigeration (2-8°C) may be necessary. Always keep the container tightly closed and ensure it is stored in a secure, well-ventilated area.