Thieno[3,2-c]pyridine-2-carboxylic acid

Basic Information

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CAS Number

86236-37-5

Molecular Formula

C8H5NO2S

Molecular Weight

179.2 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Density

1.508±0.06 g/cm3 (20 ºC 760 Torr),

SMILES

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OC(=O)c1cc2cnccc2s1

InChI

InChI=1S/C8H5NO2S/c10-8(11)7-3-5-4-9-2-1-6(5)12-7/h1-4H,(H,10,11)

InChIKey

VKOINCMQZKBKHH-UHFFFAOYSA-N

LogP

1.9945

Topological Polar Surface Area

50.19 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Synonyms & References

English

Thieno[3,2-c]pyridine-2-carboxylic acid
thieno[3,2-c]pyridine-2-carboxylic acid

MDL Number

MFCD16658570

FAQ

What are the physical and chemical properties of Thieno[3,2-c]pyridine-2-carboxylic acid (CAS: 86236-37-5)?

Thieno[3,2-c]pyridine-2-carboxylic acid (CAS: 86236-37-5) is a crystalline solid with a molecular weight of approximately 217.22 g/mol. It is slightly soluble in water and more soluble in organic solvents like dimethylformamide (DMF) and acetonitrile. Chemically, it is reactive towards nucleophiles and can undergo condensation reactions. It is stable under normal storage conditions but should be protected from moisture and light.

How is Thieno[3,2-c]pyridine-2-carboxylic acid (CAS: 86236-37-5) typically synthesized?

Thieno[3,2-c]pyridine-2-carboxylic acid (CAS: 86236-37-5) is typically synthesized via the condensation of 2-aminothieno[3,2-c]pyridine with carboxylic acid chloride or anhydride, often under a catalytic condition with a hindered base. The yield is generally high, and the product is purified by recrystallization from appropriate solvents.

What industries use Thieno[3,2-c]pyridine-2-carboxylic acid (CAS: 86236-37-5)?

Thieno[3,2-c]pyridine-2-carboxylic acid (CAS: 86236-37-5) is used in the pharmaceutical industry for drug discovery, particularly in peptide and protein synthesis. It is also used in the polymer industry for functionalizing polymers, and in the sensor industry for developing chemical and biological sensors due to its excellent solubility and reactivity.

What precautions should be taken when handling Thieno[3,2-c]pyridine-2-carboxylic acid (CAS: 86236-37-5)?

When handling Thieno[3,2-c]pyridine-2-carboxylic acid (CAS: 86236-37-5), it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. It should be stored in a cool, dry place away from moisture and light. In case of a spill, it should be cleaned up immediately using appropriate absorbent materials. Always refer to the Material Safety Data Sheet (MSDS) for specific handling and disposal instructions.