6-[(2-Amino-4-pyrimidinyl)oxy]-N-[3-(trifluoromethyl)phenyl]-1-naphthamide

Basic Information

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CAS Number

861875-60-7

Molecular Formula

C22H15F3N4O2

Molecular Weight

424.38 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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c1cc2cc(ccc2c(c1)C(=O)Nc3cccc(c3)C(F)(F)F)Oc4ccnc(n4)N

InChI

InChI=1S/C22H15F3N4O2/c23-22(24,25)14-4-2-5-15(12-14)28-20(30)18-6-1-3-13-11-16(7-8-17(13)18)31-19-9-10-27-21(26)29-19/h1-12H,(H,28,30)(H2,26,27,29)

InChIKey

MLLQJNIKDWEEFT-UHFFFAOYSA-N

LogP

5.275400000000003

Topological Polar Surface Area

90.13 Å²

Hydrogen Bond Donor/Acceptor

3 / 6

Complexity

620

Safety Information

View Safety Information

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

NVP-BAW2881
BAW2881
BAW-2881
6-(2-aminopyrimidin-4-yl)oxy-N-[3-(trifluoromethyl)phenyl]naphthalene-1-carboxamide
6-((2-aminopyrimidin-4-yl)oxy)-N-(3-(trifluoromethyl)phenyl)-1-naphthamide
6-[(2-amino-4-pyrimidinyl)oxy]-N-[3-(trifluoromethyl)phenyl]-1-naphthalenecarboxamide
NVP BAW2881
BCP17232
BDBM50270439
s8189
A12693
A917655
[(
[(3R,5S)-

MDL Number

MFCD30343850

FAQ

What are the physical and chemical properties of 6-[(2-Amino-4-pyrimidinyl)oxy]-N-[3-(trifluoromethyl)phenyl]-1-naphthamide (CAS: 861875-60-7)?

6-[(2-Amino-4-pyrimidinyl)oxy]-N-[3-(trifluoromethyl)phenyl]-1-naphthamide (CAS: 861875-60-7) is a crystalline solid with a molecular weight of approximately 508.28 g/mol. It has limited water solubility and is highly soluble in organic solvents. The compound is stable under normal laboratory conditions but may react with strong acids or bases. It shows good reactivity towards electrophiles and nucleophiles.

How is 6-[(2-Amino-4-pyrimidinyl)oxy]-N-[3-(trifluoromethyl)phenyl]-1-naphthamide (CAS: 861875-60-7) typically synthesized?

6-[(2-Amino-4-pyrimidinyl)oxy]-N-[3-(trifluoromethyl)phenyl]-1-naphthamide (CAS: 861875-60-7) is typically synthesized through a multi-step process involving the condensation of 1-naphthamide with 2-amino-4-pyrimidinol, followed by the introduction of the trifluoromethyl group. Common catalysts include sodium hydride, and the reaction is carried out in anhydrous conditions to ensure purity and yield.

What industries use 6-[(2-Amino-4-pyrimidinyl)oxy]-N-[3-(trifluoromethyl)phenyl]-1-naphthamide (CAS: 861875-60-7)?

6-[(2-Amino-4-pyrimidinyl)oxy]-N-[3-(trifluoromethyl)phenyl]-1-naphthamide (CAS: 861875-60-7) is primarily used in the pharmaceutical industry for its potential as a drug candidate. It is also explored in the electronics industry for its semi-conductive properties and in the polymer industry for its use as an additive. It has limited application in sensors and other specialized technologies.

What precautions should be taken when handling 6-[(2-Amino-4-pyrimidinyl)oxy]-N-[3-(trifluoromethyl)phenyl]-1-naphthamide (CAS: 861875-60-7)?

When handling 6-[(2-Amino-4-pyrimidinyl)oxy]-N-[3-(trifluoromethyl)phenyl]-1-naphthamide (CAS: 861875-60-7), adequate personal protective equipment (PPE) such as gloves and goggles should be worn. It should be stored in a well-ventilated area and under a fume hood during preparation. Spills should be cleaned up immediately using appropriate absorbents, and proper disposal methods should be followed. Refer to the Safety Data Sheet (SDS) for specific handling and disposal guidelines.

Related Compounds

1,3-Dibromo-2,4-dichloro-5-fluorobenzene structure

Compound Q&A

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Compound Q&A

What is 2-(2-Pyridinyl)-1,3-propanediol (CAS: 49745-42-8)?

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Compound Q&A

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What is 2-Methyl-2-propanyl 4-(5-bromo-6-methyl-2-pyridinyl)-1-piperazinecarboxylate (CAS: 1289040-88-5)?

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Compound Q&A

What is NAMPT inhibitor-linker 1 (CAS: 2241019-57-6)?

NAMPT inhibitor-linker 1 (CAS: 2241019-57-6) is a chemical compound designed as ...

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Compound Q&A

What is (2-(2,2,2-Trifluoroacetyl)pyridin-4-yl)boronic acid (CAS: 1310404-58-0)?

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1310404-58-0(2-(2,2,2-Trifluoroa...

Compound Q&A

What is 1-(2-Chlorophenyl)-6-(3,3,3-trifluoro-2-methylpropyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (CAS: 794568-90-4)?

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Compound Q&A

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6-[(2-Amino-4-pyrimidinyl)oxy]-N-[3-(trifluoromethyl)phenyl]-1-naphthamide | CAS No. 861875-60-7

Basic Information

CAS Number

Molecular Formula

Molecular Weight

Chemical Classification

Basic Physical Properties

Chemical Properties

SMILES

InChI

InChIKey

LogP

Topological Polar Surface Area

Hydrogen Bond Donor/Acceptor

Complexity

Safety Information

Hazard Statement

Synonyms & References

English

MDL Number

FAQ

What are the physical and chemical properties of 6-[(2-Amino-4-pyrimidinyl)oxy]-N-[3-(trifluoromethyl)phenyl]-1-naphthamide (CAS: 861875-60-7)?

How is 6-[(2-Amino-4-pyrimidinyl)oxy]-N-[3-(trifluoromethyl)phenyl]-1-naphthamide (CAS: 861875-60-7) typically synthesized?

What industries use 6-[(2-Amino-4-pyrimidinyl)oxy]-N-[3-(trifluoromethyl)phenyl]-1-naphthamide (CAS: 861875-60-7)?

What precautions should be taken when handling 6-[(2-Amino-4-pyrimidinyl)oxy]-N-[3-(trifluoromethyl)phenyl]-1-naphthamide (CAS: 861875-60-7)?

Related Compounds

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