1-Methyl-1H-indol-4-amine

Basic Information

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CAS Number

85696-95-3

Molecular Formula

C9H10N2

Molecular Weight

146.19 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Physical State

Yellow to Brown Sticky Oil to Semi-Solid

SMILES

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Nc1cccc2c1ccn2C

InChI

InChI=1S/C9H10N2/c1-11-6-5-7-8(10)3-2-4-9(7)11/h2-6H,10H2,1H3

InChIKey

ODOJPFQQFJVNMD-UHFFFAOYSA-N

LogP

1.7605

Topological Polar Surface Area

30.95 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Safety Information

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GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Synonyms & References

English

1-Methyl-1H-indol-4-amine
1-Methyl-1H-indol-4-ylamine
1-methylindol-4-amine
1-METHYL-1H-INDOLE-4-AMINE
1-methyl-4-indolamine
4-amino-1-methylbenzoindole
4-amino-1-methylindole
4-amino-N-methyl-indole
4-Amino-N-methylindole
N1-methyl-4-aminoindole
N-methyl-4-aminoindole
1-methyl-1H-indol-4-amine

MDL Number

MFCD08061153

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 1-Methyl-1H-indol-4-amine (CAS: 85696-95-3)?

1-Methyl-1H-indol-4-amine is a solid with a crystalline form. Its molecular weight is approximately 154.23 g/mol. This compound has limited water solubility and is soluble in common organic solvents like methanol and ethanol. It is relatively stable but can undergo deamination under basic conditions. It shows reactivity towards nucleophiles and electrophiles, making it useful in various synthetic processes.

How is 1-Methyl-1H-indol-4-amine (CAS: 85696-95-3) typically synthesized?

1-Methyl-1H-indol-4-amine can be synthesized through a classic indole modification reaction, where indole is reacted with methylamine under basic conditions. Alternatively, it can be obtained by the reduction of 1-methyl-1H-indole-4-carboxylic acid. The synthesis typically involves the use of sodium hydride as a base and ethanol as a solvent, providing good yields and selectivity.

What industries use 1-Methyl-1H-indol-4-amine (CAS: 85696-95-3)?

1-Methyl-1H-indol-4-amine is used in various industries. In pharmaceuticals, it serves as a precursor for the synthesis of novel drugs. In the polymer industry, it can be incorporated into polymer structures to enhance their properties. Additionally, it is used in the development of sensors and semiconductors due to its electronic properties.

What precautions should be taken when handling 1-Methyl-1H-indol-4-amine (CAS: 85696-95-3)?

When handling 1-Methyl-1H-indol-4-amine, it is crucial to use proper personal protective equipment (PPE), including gloves and safety goggles. The compound should be handled in a well-ventilated area or a fume hood to minimize inhalation risk. In case of a spill, immediately clean it up using appropriate absorbents and dispose of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.