1-Methyl-1H-indol-4-amine(CAS: 85696-95-3)

1-Methyl-1H-indol-4-amine is a solid with a crystalline form. Its molecular weight is approximately 154.23 g/mol. This compound has limited water solubility and is soluble in common organic solvents like methanol and ethanol. It is relatively stable but can undergo deamination under basic conditions. It shows reactivity towards nucleophiles and electrophiles, making it useful in various synthetic processes.

1-Methyl-1H-indol-4-amine can be synthesized through a classic indole modification reaction, where indole is reacted with methylamine under basic conditions. Alternatively, it can be obtained by the reduction of 1-methyl-1H-indole-4-carboxylic acid. The synthesis typically involves the use of sodium hydride as a base and ethanol as a solvent, providing good yields and selectivity.

1-Methyl-1H-indol-4-amine is used in various industries. In pharmaceuticals, it serves as a precursor for the synthesis of novel drugs. In the polymer industry, it can be incorporated into polymer structures to enhance their properties. Additionally, it is used in the development of sensors and semiconductors due to its electronic properties.

When handling 1-Methyl-1H-indol-4-amine, it is crucial to use proper personal protective equipment (PPE), including gloves and safety goggles. The compound should be handled in a well-ventilated area or a fume hood to minimize inhalation risk. In case of a spill, immediately clean it up using appropriate absorbents and dispose of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.