Lorcaserin Hydrochloride Hemihydrate

Basic Information

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CAS Number

856681-05-5

Molecular Formula

2[C11H14NCl].2[HCl].H2O

Molecular Weight

482.31 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

SMILES

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C[C@H]1CNCCC2=C1C=C(C=C2)Cl.Cl.O

InChI

InChI=1S/C11H14ClN.ClH.H2O/c1-8-7-13-5-4-9-2-3-10(12)6-11(8)9;;/h2-3,6,8,13H,4-5,7H2,1H3;1H;1H2/t8-;;/m0../s1

InChIKey

NBENLXSMFWRJRU-JZGIKJSDSA-N

LogP

7.37570

Topological Polar Surface Area

43.53 Å²

Hydrogen Bond Donor/Acceptor

3 / 2

Synonyms & References

English

Lorcaserin hydrochloride hemihydrate
(1R)-8-Chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine hydrochloride hemihydrate
(5R)-7-chloro-5-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine,hydrate,dihydrochloride
Lorcaserin HCl Hemihydrate
Belviq
Lorerin hydrochloride hemihydrate
UNII-REV26SR2B4
R-Lorcaserin hydrochloride hemehydrate
R-Lorcaserin hydrochloride hemihydrate

MDL Number

MFCD28144041

FAQ

What are the physical and chemical properties of Lorcaserin Hydrochloride Hemihydrate (CAS: 856681-05-5)?

Lorcaserin Hydrochloride Hemihydrate (CAS: 856681-05-5) is a white or off-white crystalline powder. Its molecular weight is approximately 518.74 g/mol. It is slightly soluble in water and ethanol. The compound is stable under normal conditions but should be protected from moisture to prevent degradation.

How is Lorcaserin Hydrochloride Hemihydrate (CAS: 856681-05-5) typically synthesized?

Lorcaserin Hydrochloride Hemihydrate is typically synthesized through a multi-step process involving the condensation of 2-aminobenzamide with 4-(aminomethyl)benzonitrile followed by hydrolysis and derivatization steps. The reaction involves the use of catalysts and solvents, resulting in a high yield and good selectivity.

What industries use Lorcaserin Hydrochloride Hemihydrate (CAS: 856681-05-5)?

Lorcaserin Hydrochloride Hemihydrate (CAS: 856681-05-5) is primarily used in the pharmaceutical industry for the treatment of obesity. It has also shown potential in other applications, such as in the development of sensors and as a component in certain polymers.

What precautions should be taken when handling Lorcaserin Hydrochloride Hemihydrate (CAS: 856681-05-5)?

Lorcaserin Hydrochloride Hemihydrate should be handled in a well-ventilated area or a fume hood to avoid inhalation of dust. It is recommended to use personal protective equipment such as gloves, goggles, and a lab coat. Spills should be cleaned up immediately using appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for detailed safety information.