tert-butyl N-(6-methoxy-2-pyridyl)carbamate

Basic Information

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CAS Number

855784-40-6

Molecular Formula

C11H16N2O3

Molecular Weight

224.26 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Boiling Point

275.3℃/760mmHg

SMILES

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COc1cccc(NC(=O)OC(C)(C)C)n1

InChI

InChI=1S/C11H16N2O3/c1-11(2,3)16-10(14)13-8-6-5-7-9(12-8)15-4/h5-7H,1-4H3,(H,12,13,14)

InChIKey

BDYLIANVYQWWNB-UHFFFAOYSA-N

LogP

2.4372000000000007

Topological Polar Surface Area

60.45 Å²

Hydrogen Bond Donor/Acceptor

1 / 5

Complexity

238

Safety Information

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Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

tert-Butyl (6-methoxypyridin-2-yl)carbamate
(6-Methoxy-pyridin-2-yl)-carbamic acid tert-butyl ester
Carbamic acid,(6-methoxy-2-pyridinyl)-, 1,1-dimethylethyl ester (9CI)
tert-butyl N-(6-methoxypyridin-2-yl)carbamate
Tert-butyl 6-methoxypyridin-2-ylcarbamate
(6-Methoxy-Phenyl-2-yl)Carbamic Acid Tert-Butyl Ester
2-(Boc-amino)-6-methoxypyridine
(6-Methoxy-pyridin-2-yl)-carbamic acidtert-butyl ester
PubChem16542
0797AF
AB42527
AK129696
SY034729
A841370

MDL Number

MFCD07779518

Customs Code

2933399090

FAQ

What are the physical and chemical properties of tert-butyl N-(6-methoxy-2-pyridyl)carbamate (CAS: 855784-40-6)?

Tert-butyl N-(6-methoxy-2-pyridyl)carbamate (CAS: 855784-40-6) is a white to off-white crystalline solid with a molecular weight of approximately 248.24 g/mol. It is slightly soluble in water but readily soluble in organic solvents such as ethanol and acetone. The compound is chemically stable under normal storage conditions but should be protected from strong oxidizers and acids. It is known for its reactivity in esterification and amide formation reactions.

How is tert-butyl N-(6-methoxy-2-pyridyl)carbamate (CAS: 855784-40-6) typically synthesized?

Tert-butyl N-(6-methoxy-2-pyridyl)carbamate (CAS: 855784-40-6) is synthesized via a multi-step process involving the reaction of 6-methoxy-2-pyridinecarboxylic acid with tert-butyl isocyanate. Commonly, the synthesis involves the use of anhydrous conditions and a catalytic amount of a base such as triethylamine. The reaction yields a high purity product with good selectivity, typically around 90% yield.

What industries use tert-butyl N-(6-methoxy-2-pyridyl)carbamate (CAS: 855784-40-6)?

Tert-butyl N-(6-methoxy-2-pyridyl)carbamate (CAS: 855784-40-6) is primarily used in the pharmaceutical industry for the synthesis of various biologically active compounds. It is also utilized in the polymer industry for improving the properties of certain polymers. Additionally, it has applications in sensor technology and organic synthesis due to its chemical reactivity and stability.

What precautions should be taken when handling tert-butyl N-(6-methoxy-2-pyridyl)carbamate (CAS: 855784-40-6)?

When handling tert-butyl N-(6-methoxy-2-pyridyl)carbamate (CAS: 855784-40-6), it is important to use appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work should be carried out in a well-ventilated area or under a fume hood to avoid inhalation of vapors. Spills should be handled with caution, using appropriate absorbents, and the area should be cleaned thoroughly. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal information.