(2-Ethoxy-3-pyridinyl)boronic acid

Basic Information

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CAS Number

854373-97-0

Molecular Formula

C7H10BNO3

Molecular Weight

166.97 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

SMILES

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B(C1=C(N=CC=C1)OCC)(O)O

InChI

InChI=1S/C7H10BNO3/c1-2-12-7-6(8(10)11)4-3-5-9-7/h3-5,10-11H,2H2,1H3

InChIKey

FXUMKSCYKPOZOO-UHFFFAOYSA-N

LogP

-0.8399000000000001

Topological Polar Surface Area

62.58 Å²

Hydrogen Bond Donor/Acceptor

2 / 4

Complexity

134

Safety Information

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GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

2-Ethoxypyridine-3-boronic acid
(2-Ethoxypyridin-3-yl)boronic acid
2-ETHOXY-3-PYRIDINEBORONIC ACID
2-ethoxypyridin-3-ylboronic acid
(2-ETHOXY-3-PYRIDYL)BORONIC ACID
PubChem5119
2-Ethoxypyridine-3-boronicAcid
FXUMKSCYKPOZOO-UHFFFAOYSA-N
ZXBA000450
(2-ethoxy-3-pyridinyl)boronic acid
OR9499
FCH919522
SBB052569
2-ethoxypyridine-3-boronic acid

MDL Number

MFCD06201036

Customs Code

2933399090

FAQ

What are the physical and chemical properties of (2-Ethoxy-3-pyridinyl)boronic acid (CAS: 854373-97-0)?

(2-Ethoxy-3-pyridinyl)boronic acid is a crystalline solid with a molecular weight of approximately 265.2 g/mol. It has a low water solubility and good solubility in organic solvents like THF and DMSO. Reactivity-wise, it exhibits typical boronic acid reactivity, such as in Suzuki-Miyaura cross-coupling reactions. It is stable under normal storage conditions but should be protected from moisture and light.

How is (2-Ethoxy-3-pyridinyl)boronic acid (CAS: 854373-97-0) typically synthesized?

(2-Ethoxy-3-pyridinyl)boronic acid can be synthesized by the reaction of 3-pyridylboronic acid with ethoxyborane, followed by purification. Alternatively, it can be prepared from ethoxylation of 3-pyridylboronic acid. The reaction is typically carried out under an inert atmosphere to prevent decomposition. The yield is moderate to good, and the product is usually isolated by recrystallization.

What industries use (2-Ethoxy-3-pyridinyl)boronic acid (CAS: 854373-97-0)?

(2-Ethoxy-3-pyridinyl)boronic acid is primarily used in the pharmaceutical industry for the synthesis of drug intermediates. It also finds applications in the polymer industry for the preparation of functionalized polymers, and in the sensor industry for the development of chemical sensors. Additionally, it is used in semiconductor manufacturing for surface treatments and as a precursor in various chemical processes.

What precautions should be taken when handling (2-Ethoxy-3-pyridinyl)boronic acid (CAS: 854373-97-0)?

When handling (2-Ethoxy-3-pyridinyl)boronic acid, it is important to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.