(2-Ethoxy-3-pyridinyl)boronic acid(CAS: 854373-97-0)

(2-Ethoxy-3-pyridinyl)boronic acid is a crystalline solid with a molecular weight of approximately 265.2 g/mol. It has a low water solubility and good solubility in organic solvents like THF and DMSO. Reactivity-wise, it exhibits typical boronic acid reactivity, such as in Suzuki-Miyaura cross-coupling reactions. It is stable under normal storage conditions but should be protected from moisture and light.

(2-Ethoxy-3-pyridinyl)boronic acid can be synthesized by the reaction of 3-pyridylboronic acid with ethoxyborane, followed by purification. Alternatively, it can be prepared from ethoxylation of 3-pyridylboronic acid. The reaction is typically carried out under an inert atmosphere to prevent decomposition. The yield is moderate to good, and the product is usually isolated by recrystallization.

(2-Ethoxy-3-pyridinyl)boronic acid is primarily used in the pharmaceutical industry for the synthesis of drug intermediates. It also finds applications in the polymer industry for the preparation of functionalized polymers, and in the sensor industry for the development of chemical sensors. Additionally, it is used in semiconductor manufacturing for surface treatments and as a precursor in various chemical processes.

When handling (2-Ethoxy-3-pyridinyl)boronic acid, it is important to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.