3-Chloro-5-(trifluoromethyl)pyridine

Basic Information

View in Editor

CAS Number

85148-26-1

Molecular Formula

C6H3ClF3N

Molecular Weight

181.54 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Melting Point

23-27 °C

Boiling Point

133-138 °C

Refractive Index

1.4460 to 1.4500

SMILES

View in Editor

C1=C(C=NC=C1Cl)C(F)(F)F

InChI

InChI=1S/C6H3ClF3N/c7-5-1-4(2-11-3-5)6(8,9)10/h1-3H

InChIKey

OMRCXTBFBBWTDL-UHFFFAOYSA-N

LogP

2.7538

Topological Polar Surface Area

12.89 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

136

Safety Information

View Safety Information

GHS Hazard Pictograms

H301

H315

H319

H335

Hazard Statement

H301 Toxic if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class 6.1 Class 6.1

Synonyms & References

English

3-Chloro-5-(trifluoromethyl)pyridine
3-chloro-5-trifluoromethylpyridine
3-chloro-5-trifluoromethyl-pyridine
3-Trifluoromethyl-5-chloropyridine
3-chloro-5-(trifluoromethyl)pyridine
AKOS005063769
3-Chloro-5-trifluoromethylpyridine
PS-6449
3-Chloro-5-(trifluoromethyl)pyridine-carbonitrile
CS-W002205
3-Chloro-5-(trifluoromethyl)pyridine, 97%
85148-26-1
STL555360
PB18435
C2951
EN300-114758
Pyridine, 3-chloro-5-(trifluoromethyl)-
SCHEMBL876019
AC-23348
Q-101483
BBL101564
J-512259
DB-003925
MFCD00042227
DTXSID30371538
3-trifluoromethyl-5-chloropyridine

MDL Number

MFCD00042227

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 3-Chloro-5-(trifluoromethyl)pyridine (CAS: 85148-26-1)?

3-Chloro-5-(trifluoromethyl)pyridine is a crystalline solid with a molecular weight of approximately 229.57 g/mol. It has a low solubility in water but is soluble in organic solvents like dichloromethane and acetone. The compound shows moderate reactivity towards nucleophiles and is stable under normal conditions.

How is 3-Chloro-5-(trifluoromethyl)pyridine (CAS: 85148-26-1) typically synthesized?

3-Chloro-5-(trifluoromethyl)pyridine is typically synthesized by chlorinating 5-(trifluoromethyl)pyridine in the presence of a Lewis acid catalyst, such as boron trifluoride etherate, followed by removal of hydrochloric acid through distillation.

What industries use 3-Chloro-5-(trifluoromethyl)pyridine (CAS: 85148-26-1)?

3-Chloro-5-(trifluoromethyl)pyridine is primarily used in the pharmaceutical industry for the synthesis of various drug intermediates. It is also utilized in the polymer industry for the production of functional monomers and in the sensor industry for developing gas sensors.

What precautions should be taken when handling 3-Chloro-5-(trifluoromethyl)pyridine (CAS: 85148-26-1)?

When handling 3-Chloro-5-(trifluoromethyl)pyridine, it is important to use appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up according to the Material Safety Data Sheet (MSDS) guidelines.