3-Chloro-5-(trifluoromethyl)pyridine(CAS: 85148-26-1)

3-Chloro-5-(trifluoromethyl)pyridine is a crystalline solid with a molecular weight of approximately 229.57 g/mol. It has a low solubility in water but is soluble in organic solvents like dichloromethane and acetone. The compound shows moderate reactivity towards nucleophiles and is stable under normal conditions.

3-Chloro-5-(trifluoromethyl)pyridine is typically synthesized by chlorinating 5-(trifluoromethyl)pyridine in the presence of a Lewis acid catalyst, such as boron trifluoride etherate, followed by removal of hydrochloric acid through distillation.

3-Chloro-5-(trifluoromethyl)pyridine is primarily used in the pharmaceutical industry for the synthesis of various drug intermediates. It is also utilized in the polymer industry for the production of functional monomers and in the sensor industry for developing gas sensors.

When handling 3-Chloro-5-(trifluoromethyl)pyridine, it is important to use appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up according to the Material Safety Data Sheet (MSDS) guidelines.