(3R)-oxolan-3-ol

Basic Information

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CAS Number

84976-47-6

Molecular Formula

C4H8O2

Molecular Weight

88.11 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Boiling Point

80 °C15 mm Hg

Density

1.103 g/mL at 25 °C

Flash Point

175 °F

Refractive Index

n20/D 1.45(lit.)

Specific Rotation

18.5 o (C=2 MEOH)

SMILES

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O[C@H]1COCC1

InChI

InChI=1S/C4H8O2/c5-4-1-2-6-3-4/h4-5H,1-3H2/t4-/m1/s1

InChIKey

XDPCNPCKDGQBAN-SCSAIBSYSA-N

LogP

-0.23239999999999994

Topological Polar Surface Area

29.46 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

44.8

Synonyms & References

English

3-FURANOL, TETRAHYDRO-, (S)
(S)-(+)-3-HYDROXY TETAHYDRO FURAN
(S)-(+)-3-HYDROXYTETRAHYDROFURANE
(S)-TETRAHYDROFURAN-3-OL
(S)-(-)-3-HYDOXY-TETRAHYDRO-FURAN
(R)-3-Hydroxytetrahydrofu...
(S)-(+)-TETRAHYDRO-3-FURANOL(RS20010093)
2-Furanyl,tetrahydro-3-hydroxy-, (R)-
2-Furanyl,tetrahydro-3-hydroxy-, (R)- (9CI)
(S)-(-)-Tetrahydrofuran-3-ol
(S)-(+)-3-HYDROXYTETRAHYDROFURAN
S)-(-)-3-HYDOXY TETAHYDRO TETRAHYDRO FURAN
3-HYDROXYTETRAHYDROFURAN
Tetrahydrofuran-3-ol
oxolan-3-ol
3-Furanol, tetrahydro-
Tetrahydro-3-furanol
Tetrahydro-furan-3-ol
3-Hydroxyoxolane
3-hydroxytetrahydrofurane
3-hydroxy tetrahydrofuran
(S) 3-Hydroxytetrahydrofuran
S-3-Hydroxytetrahydrofuran
3-tetrahydrofuranol
NSC71875
tetrahydrofuran-4-ol
3-hydroxytetrahydofuran
3-hydroxy-tetrahydrofuran
3-hydroxy tetrahydrofurane
3-hydroxy-tetrah

MDL Number

MFCD00064327

Customs Code

2932190090

FAQ

What are the physical and chemical properties of (3R)-oxolan-3-ol (CAS: 84976-47-6)?

(3R)-Oxolan-3-ol is a colorless liquid with a molecular weight of approximately 92.09 g/mol. It is slightly soluble in water but miscible with ethanol and ether. It is chemically reactive, particularly with acids and bases, and can participate in condensation reactions and esterification. The compound crystallizes in the form of white needles at low temperatures.

How is (3R)-oxolan-3-ol (CAS: 84976-47-6) typically synthesized?

(3R)-Oxolan-3-ol can be synthesized via the reduction of (3R)-oxolane-3-carboxylic acid with lithium aluminum hydride (LAH) as a common reducing agent. Another method involves the hydrolysis of (3R)-oxolane-3-carboxylate sodium, yielding the alcohol with high purity and selectivity. The reaction conditions are crucial for maintaining high yield and product purity.

What industries use (3R)-oxolan-3-ol (CAS: 84976-47-6)?

(3R)-Oxolan-3-ol finds applications in the pharmaceutical industry as an intermediate for drug synthesis, particularly in the production of certain antibiotics and antifungals. It is also used in the polymer industry as a monomer for the synthesis of various polymers with unique properties. Additionally, it has applications in the production of sensors and semiconductors due to its chemical reactivity and structural characteristics.

What precautions should be taken when handling (3R)-oxolan-3-ol (CAS: 84976-47-6)?

When handling (3R)-oxolan-3-ol, it is important to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. Work should be conducted in a well-ventilated area or fume hood to minimize inhalation risks. Spills should be carefully cleaned up using absorbent materials, and the area should be well-vented. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information and emergency procedures.