(3R)-oxolan-3-ol(CAS: 84976-47-6)

(3R)-Oxolan-3-ol is a colorless liquid with a molecular weight of approximately 92.09 g/mol. It is slightly soluble in water but miscible with ethanol and ether. It is chemically reactive, particularly with acids and bases, and can participate in condensation reactions and esterification. The compound crystallizes in the form of white needles at low temperatures.

(3R)-Oxolan-3-ol can be synthesized via the reduction of (3R)-oxolane-3-carboxylic acid with lithium aluminum hydride (LAH) as a common reducing agent. Another method involves the hydrolysis of (3R)-oxolane-3-carboxylate sodium, yielding the alcohol with high purity and selectivity. The reaction conditions are crucial for maintaining high yield and product purity.

(3R)-Oxolan-3-ol finds applications in the pharmaceutical industry as an intermediate for drug synthesis, particularly in the production of certain antibiotics and antifungals. It is also used in the polymer industry as a monomer for the synthesis of various polymers with unique properties. Additionally, it has applications in the production of sensors and semiconductors due to its chemical reactivity and structural characteristics.

When handling (3R)-oxolan-3-ol, it is important to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. Work should be conducted in a well-ventilated area or fume hood to minimize inhalation risks. Spills should be carefully cleaned up using absorbent materials, and the area should be well-vented. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information and emergency procedures.