(2S)-2-{Diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine

Basic Information

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CAS Number

848821-58-9

Molecular Formula

C20H27NOSi

Molecular Weight

325.53 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Physical State

Pale-yellow to Yellow-brown Solid

Melting Point

No data available

Boiling Point

412.7±35.0 °C at 760 mmHg

Density

0.860 g/mL at 25 °C

Refractive Index

n20/D 1.498

Specific Rotation

-45.0° (c=1, chloroform)

SMILES

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C[Si](OC(c1ccccc1)(c1ccccc1)[C@@H]1CCCN1)(C)C

InChI

InChI=1S/C20H27NOSi/c1-23(2,3)22-20(19-15-10-16-21-19,17-11-6-4-7-12-17)18-13-8-5-9-14-18/h4-9,11-14,19,21H,10,15-16H2,1-3H3/t19-/m0/s1

InChIKey

RSUHWMSTWSSNOW-IBGZPJMESA-N

LogP

4.533700000000003

Topological Polar Surface Area

21.259999999999998 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

(S)-2-(Diphenyl((trimethylsilyl)oxy)methyl)pyrrolidine
S-(-)-α,α-Diphenyl-2-pyrrolidinemethanol trimethylsilyl ether
(S)-(-)-alpha,alpha-Diphenyl-2-pyrrolidinemethanol Trimethylsilyl Ether
(R)-(+)-ALPHA,ALPHA-DIPHENYL-2-PYRROLIDINYL METHYLTMS ETHER
(S)-(-)-ALPHA,ALPHA-DIPHENYL-2-PYRROLIDINYL METHYLTMS ETHER
(S)-(-)-Α,Α-DIPHENYL-2-PYRROLIDINE METHANOLTRIMETHYLSILYL ETHER
(S)-2-(Diphenyl((trimethylsilyl)-oxy)methyl)pyrrolidine
[diphenyl-[(2S)-pyrrolidin-2-yl]methoxy]-trimethylsilane
Pyrrolidine, 2-[diphenyl[(trimethylsilyl)oxy]methyl]-, (2S)-
(S)-2-(Diphenyl(TriMethylsilyloxy)Methyl)Pyrrolidine
,&alpha
i>)-(–)-&alpha
α,α-Diphenyl-L-prolinol Trimethylsilyl Ether
(S)-(-)-2-[Diphenyl(trimethylsilyloxy)methyl]pyrrolidine
(S)-Hayashi-Jorgensen Catalyst
(S)-2-[Diphenyl(Trimethylsilanyloxy)Methyl]Pyrrolidine
[diphenyl-[(2S)-pyrrolidin-2-yl]methoxy]-trimethyl-silane

MDL Number

MFCD08690083

Customs Code

2933990090

FAQ

What is (2S)-2-{Diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine (CAS: 848821-58-9)?

(2S)-2-{Diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine is a chiral organic compound with a unique structure that includes a pyrrolidine ring, a silyl ether group, and phenyl substituents. It is characterized by its high boiling point and low solubility in water. This compound is primarily used in medicinal chemistry and as a precursor in synthetic organic reactions.

What are the main uses of (2S)-2-{Diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine (CAS: 848821-58-9)?

(2S)-2-{Diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine (CAS: 848821-58-9) is mainly used as a synthetic intermediate in the pharmaceutical industry, particularly in the development of medicinal drugs. It also serves as a key component in the synthesis of various chemical compounds with potential applications in materials science and research.

Is (2S)-2-{Diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine (CAS: 848821-58-9) safe?

Yes, (2S)-2-{Diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine (CAS: 848821-58-9) is considered safe under proper handling conditions. However, it is important to follow safety guidelines, including wearing appropriate personal protective equipment (PPE) such as gloves and goggles to prevent skin and eye contact. Ensure good ventilation during handling and avoid inhalation of vapors.

How should (2S)-2-{Diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine (CAS: 848821-58-9) be stored?

(2S)-2-{Diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine (CAS: 848821-58-9) should be stored in a cool, dry place away from direct sunlight and heat sources. Store it in a tightly sealed container to prevent moisture absorption. Maintain a temperature range of 15-25°C and keep away from incompatible materials to ensure safety and stability.