2-Chloro-4-fluoro-5-nitrophenol

Basic Information

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CAS Number

84478-75-1

Molecular Formula

C6H3ClFNO3

Molecular Weight

191.54 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Melting Point

108.0 to 112.0 deg-C

Boiling Point

298.7℃ at 760 mmHg

Density

1.653

Flash Point

134.5℃

Refractive Index

1.598

SMILES

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OC1=CC([N+]([O-])=O)=C(F)C=C1Cl

InChI

InChI=1S/C6H3ClFNO3/c7-3-1-4(8)5(9(11)12)2-6(3)10/h1-2,10H

InChIKey

NAWVMCKMQMJQMF-UHFFFAOYSA-N

LogP

2.61610

Complexity

186

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

2-Chloro-4-fluoro-5-nitrophenol
2-chloro-4-fluro-5-nitrobezenol
1-chloro-5-fluoro-2-hydroxy-4-nitro-benzene
2-Chloro-4-fluoro-5-nitrobenzenol
4-chloro-2-fluoro-5-hydroxynitrobenzene
chlorofluoronitrobenzenol
4-Chloro-2-fluoro-5-hydroxy-1-nitrobenzene
Phenol, 2-chloro-4-fluoro-5-nitro-
2-chloro-4-fluoro-5-nitro-phenol
PubChem2849
KSC495S7H
NAWVMCKMQMJQMF-UHFFFAOYSA-N
WT191
EBD16320
SBB055201
FCH919020
CL4108
LS10398
CM11685
PC10132
VZ24230
TRA0064463
2-chloro-4-fluoro-5-nitrophenol

MDL Number

MFCD02670258

Customs Code

2908999090

FAQ

What are the physical and chemical properties of 2-Chloro-4-fluoro-5-nitrophenol (CAS: 84478-75-1)?

2-Chloro-4-fluoro-5-nitrophenol (CAS: 84478-75-1) is a crystalline solid with a molecular weight of approximately 217.58 g/mol. It is slightly soluble in water and has a high solubility in organic solvents such as ethanol and acetone. This compound is reactive towards nucleophiles and reducing agents, making it suitable for various synthetic transformations. It is known for its strong absorption in the ultraviolet region, which makes it useful in spectroscopic applications.

How is 2-Chloro-4-fluoro-5-nitrophenol (CAS: 84478-75-1) typically synthesized?

2-Chloro-4-fluoro-5-nitrophenol (CAS: 84478-75-1) can be synthesized through a multistep process involving the nitration of 4-fluoro-5-chlorophenol, followed by chlorination of the nitro derivative. This reaction typically requires strong acids such as sulfuric acid and high temperatures. The process is highly selective and yields up to 90% purity, depending on the reaction conditions and purification methods.

What industries use 2-Chloro-4-fluoro-5-nitrophenol (CAS: 84478-75-1)?

2-Chloro-4-fluoro-5-nitrophenol (CAS: 84478-75-1) is primarily used in the pharmaceutical industry for the synthesis of active pharmaceutical ingredients. It also finds applications in the polymer industry as a precursor for chemical additives and in the sensor industry due to its unique spectral properties. Additionally, it is used in the semiconductor industry for certain fabrication processes.

What precautions should be taken when handling 2-Chloro-4-fluoro-5-nitrophenol (CAS: 84478-75-1)?

When handling 2-Chloro-4-fluoro-5-nitrophenol (CAS: 84478-75-1), it is essential to wear appropriate personal protective equipment (PPE) including gloves, safety goggles, and a laboratory coat. Handle in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbent materials, and the area should be thoroughly washed down. Always consult the Safety Data Sheet (SDS) for detailed emergency response procedures.