3-Phenyl-3-(4-(trifluoromethyl)phenoxy)propan-1-amine

Basic Information

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CAS Number

83891-03-6

Molecular Formula

C16H16F3NO

Molecular Weight

295.3 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Physical State

solid

Melting Point

105-108°C

Boiling Point

381.1 °C at 760 mmHg

Density

1.204

Flash Point

184.3 °C

Solubility

H2O: >4 mg/mL

Refractive Index

1.525

SMILES

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NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F

InChI

InChI=1S/C16H16F3NO/c17-16(18,19)13-6-8-14(9-7-13)21-15(10-11-20)12-4-2-1-3-5-12/h1-9,15H,10-11,20H2

InChIKey

WIQRCHMSJFFONW-UHFFFAOYSA-N

LogP

4.174300000000003

Topological Polar Surface Area

35.25 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

294

Synonyms & References

English

Benzenepropanamine, g-[4-(trifluoromethyl)phenoxy]-
Norfluoxetine
NORFLUOXETINE HYDROCHLORIDE
N-desmethylfluoxetine
NORFLUOXETINE HCL
3-Phenyl-3-(4-trifluoromethyl-phenoxy)-propylamine

MDL Number

MFCD01321043

Customs Code

2922299090

FAQ

What are the physical and chemical properties of 3-Phenyl-3-(4-(trifluoromethyl)phenoxy)propan-1-amine (CAS: 83891-03-6)?

3-Phenyl-3-(4-(trifluoromethyl)phenoxy)propan-1-amine is a white to off-white crystalline solid. It has a molecular weight of approximately 321.2 g/mol. The compound is slightly soluble in water but more soluble in organic solvents. It exhibits low reactivity under normal conditions but reacts readily with strong bases. This compound is stable under normal storage conditions but should be protected from moisture and light.

How is 3-Phenyl-3-(4-(trifluoromethyl)phenoxy)propan-1-amine (CAS: 83891-03-6) typically synthesized?

3-Phenyl-3-(4-(trifluoromethyl)phenoxy)propan-1-amine is typically synthesized via a multistep process involving the preparation of an appropriate phenol, followed by alkylation with an appropriate amine. The synthesis often involves the use of catalytic amounts of boron trifluoride etherate and can achieve good yields. The product is isolated by recrystallization from an appropriate solvent.

What industries use 3-Phenyl-3-(4-(trifluoromethyl)phenoxy)propan-1-amine (CAS: 83891-03-6)?

3-Phenyl-3-(4-(trifluoromethyl)phenoxy)propan-1-amine is used in the pharmaceutical industry, where it serves as a precursor or intermediate in the synthesis of pharmaceuticals. It is also used in the polymer industry for modifying polymer properties and in sensor technology for its specific chemical reactivity.

What precautions should be taken when handling 3-Phenyl-3-(4-(trifluoromethyl)phenoxy)propan-1-amine (CAS: 83891-03-6)?

When handling 3-Phenyl-3-(4-(trifluoromethyl)phenoxy)propan-1-amine, appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. It should be handled in a well-ventilated area or a fume hood. In case of a spill, it should be cleaned up using appropriate absorbent materials. For detailed safety information, refer to the Material Safety Data Sheet (SDS).