Compound Q&A

How is 3-Phenyl-3-(4-(trifluoromethyl)phenoxy)propan-1-amine (CAS: 83891-03-6) typically synthesized?

Answer

3-Phenyl-3-(4-(trifluoromethyl)phenoxy)propan-1-amine
3-Phenyl-3-(4-(trifluoromethyl)phenoxy)propan-1-amine is typically synthesized via a multistep process involving the preparation of an appropriate phenol, followed by alkylation with an appropriate amine. The synthesis often involves the use of catalytic amounts of boron trifluoride etherate and can achieve good yields. The product is isolated by recrystallization from an appropriate solvent.

About

CAS No 83891-03-6
English Name 3-Phenyl-3-(4-(trifluoromethyl)phenoxy)propan-1-amine
Molecular Formula C16H16F3NO
Molecular Weight 295.3 g/mol
SMILES NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F
InChIKey WIQRCHMSJFFONW-UHFFFAOYSA-N
Last Updated: 2026-03-05 06:57

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