4-Bromo-2-(difluoromethoxy)pyridine

Basic Information

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CAS Number

832735-56-5

Molecular Formula

C6H4BrF2NO

Molecular Weight

224 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

SMILES

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FC(F)Oc1cc(Br)ccn1

InChI

InChI=1S/C6H4BrF2NO/c7-4-1-2-10-5(3-4)11-6(8)9/h1-3,6H

InChIKey

QKZHLBZNEBCOLM-UHFFFAOYSA-N

LogP

2.445500000000001

Topological Polar Surface Area

22.12 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

4-Bromo-2-(difluoromethoxy)pyridine
Pyridine, 4-bromo-2-(difluoromethoxy)-
Pyridine,4-bromo-2-(difluoromethoxy)
4-bromo-2-(difluoromethoxy)pyridine

MDL Number

MFCD14584703

FAQ

What are the physical and chemical properties of 4-Bromo-2-(difluoromethoxy)pyridine (CAS: 832735-56-5)?

4-Bromo-2-(difluoromethoxy)pyridine is a solid with a crystalline form. Its molecular weight is approximately 229.01 g/mol. It has a low solubility in water but is more soluble in organic solvents like methanol and dichloromethane. This compound exhibits moderate reactivity in the presence of bases and is stable under normal conditions. It is used as an intermediate in various organic synthesis reactions.

How is 4-Bromo-2-(difluoromethoxy)pyridine (CAS: 832735-56-5) typically synthesized?

4-Bromo-2-(difluoromethoxy)pyridine is typically synthesized via a multistep process involving bromination and subsequent fluorination of 2-(difluoromethoxy)pyridine. The reaction conditions include the use of NBS (N-bromosuccinimide) for bromination and N-fluorobenzenesulfonimide for fluorination. The yield is moderate, around 50-60%, and the reaction is selective. Detailed procedures are available in the literature.

What industries use 4-Bromo-2-(difluoromethoxy)pyridine (CAS: 832735-56-5)?

4-Bromo-2-(difluoromethoxy)pyridine is primarily used as an intermediate in pharmaceuticals and fine chemical industries. It plays a role in the synthesis of various drug molecules and functional materials. It is also employed in the development of sensors and semiconductors, although on a smaller scale.

What precautions should be taken when handling 4-Bromo-2-(difluoromethoxy)pyridine (CAS: 832735-56-5)?

Proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn when handling 4-Bromo-2-(difluoromethoxy)pyridine. It should be stored in a cool, dry place away from direct sunlight and heat sources. Spills should be cleaned up using appropriate methods and materials, and the area should be well-ventilated. Always refer to the safety data sheet (SDS) for detailed handling instructions and emergency procedures.