4-Bromo-2-(difluoromethoxy)pyridine(CAS: 832735-56-5)

4-Bromo-2-(difluoromethoxy)pyridine is a solid with a crystalline form. Its molecular weight is approximately 229.01 g/mol. It has a low solubility in water but is more soluble in organic solvents like methanol and dichloromethane. This compound exhibits moderate reactivity in the presence of bases and is stable under normal conditions. It is used as an intermediate in various organic synthesis reactions.

4-Bromo-2-(difluoromethoxy)pyridine is typically synthesized via a multistep process involving bromination and subsequent fluorination of 2-(difluoromethoxy)pyridine. The reaction conditions include the use of NBS (N-bromosuccinimide) for bromination and N-fluorobenzenesulfonimide for fluorination. The yield is moderate, around 50-60%, and the reaction is selective. Detailed procedures are available in the literature.

4-Bromo-2-(difluoromethoxy)pyridine is primarily used as an intermediate in pharmaceuticals and fine chemical industries. It plays a role in the synthesis of various drug molecules and functional materials. It is also employed in the development of sensors and semiconductors, although on a smaller scale.

Proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn when handling 4-Bromo-2-(difluoromethoxy)pyridine. It should be stored in a cool, dry place away from direct sunlight and heat sources. Spills should be cleaned up using appropriate methods and materials, and the area should be well-ventilated. Always refer to the safety data sheet (SDS) for detailed handling instructions and emergency procedures.