5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinamine

Basic Information

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CAS Number

827614-64-2

Molecular Formula

C11H17BN2O2

Molecular Weight

220.08 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

131-135 °C

Boiling Point

352.9℃ at 760 mmHg

Density

1.09

Water Solubility

Insoluble in water.

Flash Point

167.3℃

Refractive Index

1.516

SMILES

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B1(OC(C(O1)(C)C)(C)C)C2=CN=C(C=C2)N

InChI

InChI=1S/C11H17BN2O2/c1-10(2)11(3,4)16-12(15-10)8-5-6-9(13)14-7-8/h5-7H,1-4H3,(H2,13,14)

InChIKey

YFTAUNOLAHRUIE-UHFFFAOYSA-N

LogP

0.9629999999999996

Topological Polar Surface Area

57.370000000000005 Å²

Hydrogen Bond Donor/Acceptor

2 / 4

Complexity

255

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

AC-25638
2-Amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
2-amino-pyridine-5-boronic acid pinacol ester
6-Aminopyridine-3-boronic acid, pinacol ester
5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine
A840432
5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) pyridin-2-amine
DTXSID20373420
C11H17BN2O2
CS-W000973
(6-AMINOPYRIDIN-3-YL)BORONIC ACID PINACOL ESTER
SY005789
A15831
5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridin-2-ylamine
5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-ylamine
J-508073
5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinamine
2-aminopyridine-5-boronic acid, pinacol ester
2-Pyridinamine, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
6-Aminopyridine-3-boronic acid pinacol ester
YFTAUNOLAHRUIE-UHFFFAOYSA-N
2-Aminopyridine-5-boronic acid pinacol ester
GS-6327
2-Aminopyridine-5-boronic acid pinacol ester, 97%
FT-0647397
EN300-97678
5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-ylamine
BCP10062
5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine
2-amino-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine
5-(4,4,5,5-tetramethyl-[1,3,2]dioxa borolan-2-yl)-pyridin-2-ylamine

MDL Number

MFCD05663837

FAQ

What are the physical and chemical properties of 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinamine (CAS: 827614-64-2)?

5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinamine is a colorless solid with a molecular weight of approximately 362.4 g/mol. It has a solubility of about 10 mg/mL in water and is soluble in organic solvents like DMSO and DMF. The compound is known for its reactivity with boronic acids and esters, making it useful in organic synthesis. It is also stable under standard storage conditions but should be protected from moisture.

How is 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinamine (CAS: 827614-64-2) typically synthesized?

5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinamine can be synthesized by the reaction of 2-pyridinamine with 1,1,1,3,3,3-hexafluoro-2-propanol in the presence of a base like cesium carbonate. The reaction is typically carried out in DMF at room temperature. The product is isolated by filtration and can be further purified by recrystallization or column chromatography.

What industries use 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinamine (CAS: 827614-64-2)?

5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinamine is utilized in the pharmaceutical industry for the synthesis of drug intermediates. It is also used in the polymer industry for the preparation of boron-containing polymers. Additionally, it has potential applications in the development of sensors and semiconductors due to its unique chemical properties.

What precautions should be taken when handling 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinamine (CAS: 827614-64-2)?

When handling 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinamine, it is important to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a cool, dry place away from moisture. In case of a spill, it should be carefully cleaned up using appropriate absorbent materials. Always consult the Safety Data Sheet (SDS) for detailed handling and safety information.