(2-Bromo-4-methylphenyl)methanol

Basic Information

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CAS Number

824-53-3

Molecular Formula

C8H9BrO

Molecular Weight

201.06 g/mol

Chemical Classification

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

SMILES

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CC1=CC(=C(C=C1)CO)Br

InChI

InChI=1S/C8H9BrO/c1-6-2-3-7(5-10)8(9)4-6/h2-4,10H,5H2,1H3

InChIKey

RAJNCYHWPIQECA-UHFFFAOYSA-N

LogP

2.24982

Topological Polar Surface Area

20.23 Å²

Hydrogen Bond Donor/Acceptor

1 / 1

Complexity

105

Synonyms & References

English

2-Bromo-4-methylbenzyl alcohol
Benzenemethanol, 2-bromo-4-methyl-
(2-Bromo-4-methylphenyl)methanol
FT-0702627
RAJNCYHWPIQECA-UHFFFAOYSA-N
824-53-3
AS-9720
AKOS017560250
DTXSID80728972
SCHEMBL1588133
E89840
CS-0194373
MFCD06202838

MDL Number

MFCD06202838

FAQ

What are the physical and chemical properties of (2-Bromo-4-methylphenyl)methanol (CAS: 824-53-3)?

(2-Bromo-4-methylphenyl)methanol is a colorless to yellow liquid with a molecular weight of 206.01 g/mol. It has a low solubility in water (0.5 g/L at 20°C) but is more soluble in organic solvents. It exhibits moderate reactivity, particularly with nucleophiles, and is prone to bromine substitution reactions.

How is (2-Bromo-4-methylphenyl)methanol (CAS: 824-53-3) typically synthesized?

(2-Bromo-4-methylphenyl)methanol is commonly synthesized by the bromination of 4-methylphenylmethanol followed by purification. This process uses bromine in an acidic medium, often with phosphorus pentoxide as a catalyst. The reaction is carried out under reflux conditions, and the product is isolated by distillation or recrystallization.

What industries use (2-Bromo-4-methylphenyl)methanol (CAS: 824-53-3)?

(2-Bromo-4-methylphenyl)methanol is primarily used in the pharmaceutical and fine chemical industries. It serves as a precursor in the synthesis of various drugs and organobromine compounds. Additionally, it may be used in the production of polymers and as a reagent in analytical chemistry and chemical research.

What precautions should be taken when handling (2-Bromo-4-methylphenyl)methanol (CAS: 824-53-3)?

When handling (2-Bromo-4-methylphenyl)methanol, it is important to use personal protective equipment (PPE) including safety goggles, gloves, and lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up immediately using appropriate absorbent materials, and the area should be flushed with water. Always refer to a safety data sheet (SDS) for detailed handling and disposal instructions.