(2-Bromo-4-methylphenyl)methanol(CAS: 824-53-3)

(2-Bromo-4-methylphenyl)methanol is a colorless to yellow liquid with a molecular weight of 206.01 g/mol. It has a low solubility in water (0.5 g/L at 20°C) but is more soluble in organic solvents. It exhibits moderate reactivity, particularly with nucleophiles, and is prone to bromine substitution reactions.

(2-Bromo-4-methylphenyl)methanol is commonly synthesized by the bromination of 4-methylphenylmethanol followed by purification. This process uses bromine in an acidic medium, often with phosphorus pentoxide as a catalyst. The reaction is carried out under reflux conditions, and the product is isolated by distillation or recrystallization.

(2-Bromo-4-methylphenyl)methanol is primarily used in the pharmaceutical and fine chemical industries. It serves as a precursor in the synthesis of various drugs and organobromine compounds. Additionally, it may be used in the production of polymers and as a reagent in analytical chemistry and chemical research.

When handling (2-Bromo-4-methylphenyl)methanol, it is important to use personal protective equipment (PPE) including safety goggles, gloves, and lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up immediately using appropriate absorbent materials, and the area should be flushed with water. Always refer to a safety data sheet (SDS) for detailed handling and disposal instructions.