2-Chloro-4,6-bis(trifluoromethyl)pyridine | CAS No. 81565-21-1
2-Chloro-4,6-bis(trifluoromethyl)pyridine
Basic Information
CAS Number
81565-21-1
Molecular Formula
C7H2ClF6N
Molecular Weight
249.54 g/mol
AD
Basic Physical Properties
Boiling Point
142.4°C at 760 mmHg
Density
1.543
Flash Point
62.8°C
Refractive Index
1.4
Synonyms & References
English
- 81565-21-1
- E86797
- MFCD00082557
- DTXSID20563425
- Pyridine, 2-chloro-4,6-bis(trifluoromethyl)-
- AB03094
- FT-0777836
- 2-CHLORO-4,6-BIS(TRIFLUOROMETHYL)PYRIDINE
- AKOS028114027
- Pyridine,2-chloro-4,6-bis(trifluoromethyl)-
- EN300-1654989
- SCHEMBL4703323
- CS-0235935
MDL Number
MFCD00082557
FAQ
What are the physical and chemical properties of 2-Chloro-4,6-bis(trifluoromethyl)pyridine (CAS: 81565-21-1)?
2-Chloro-4,6-bis(trifluoromethyl)pyridine (CAS: 81565-21-1) is a crystalline solid with a high molecular weight. It has low aqueous solubility and is soluble in organic solvents. This compound is highly reactive due to the presence of the chlorine and trifluoromethyl groups. It is stable under normal conditions but can react with nucleophiles under certain conditions.
How is 2-Chloro-4,6-bis(trifluoromethyl)pyridine (CAS: 81565-21-1) typically synthesized?
2-Chloro-4,6-bis(trifluoromethyl)pyridine is typically synthesized via alkylation of 4,6-dichloropyridine with trifluoromethyl chloride in the presence of a base like potassium tert-butoxide. The reaction yields a high purity of the product with good selectivity and yield, making it a suitable method for large-scale production.
What industries use 2-Chloro-4,6-bis(trifluoromethyl)pyridine (CAS: 81565-21-1)?
2-Chloro-4,6-bis(trifluoromethyl)pyridine (CAS: 81565-21-1) finds applications in the pharmaceutical industry for the synthesis of certain drug intermediates, as well as in the electronics industry for use in semiconductor manufacturing. It is also utilized in the polymer industry for special applications requiring high stability and specific chemical functionalities.
What precautions should be taken when handling 2-Chloro-4,6-bis(trifluoromethyl)pyridine (CAS: 81565-21-1)?
When handling 2-Chloro-4,6-bis(trifluoromethyl)pyridine (CAS: 81565-21-1), it is essential to use appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. This compound should be used in a fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate methods, and the Material Safety Data Sheet (MSDS) should be consulted for detailed safety information.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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