2-Chloro-4,6-bis(trifluoromethyl)pyridine(CAS: 81565-21-1)

2-Chloro-4,6-bis(trifluoromethyl)pyridine (CAS: 81565-21-1) is a crystalline solid with a high molecular weight. It has low aqueous solubility and is soluble in organic solvents. This compound is highly reactive due to the presence of the chlorine and trifluoromethyl groups. It is stable under normal conditions but can react with nucleophiles under certain conditions.

2-Chloro-4,6-bis(trifluoromethyl)pyridine is typically synthesized via alkylation of 4,6-dichloropyridine with trifluoromethyl chloride in the presence of a base like potassium tert-butoxide. The reaction yields a high purity of the product with good selectivity and yield, making it a suitable method for large-scale production.

2-Chloro-4,6-bis(trifluoromethyl)pyridine (CAS: 81565-21-1) finds applications in the pharmaceutical industry for the synthesis of certain drug intermediates, as well as in the electronics industry for use in semiconductor manufacturing. It is also utilized in the polymer industry for special applications requiring high stability and specific chemical functionalities.

When handling 2-Chloro-4,6-bis(trifluoromethyl)pyridine (CAS: 81565-21-1), it is essential to use appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. This compound should be used in a fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate methods, and the Material Safety Data Sheet (MSDS) should be consulted for detailed safety information.