Methyl 4-piperidinylacetate hydrochloride (1:1)

Basic Information

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CAS Number

81270-37-3

Molecular Formula

C8H16ClNO2

Molecular Weight

193.67 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Physical State

PURPLE POWDER

Melting Point

153.0 to 157.0 deg-C

Boiling Point

253°C at 760 mmHg

Flash Point

106.8℃

SMILES

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Cl.COC(=O)CC1CCNCC1

InChI

InChI=1S/C8H15NO2.ClH/c1-11-8(10)6-7-2-4-9-5-3-7;/h7,9H,2-6H2,1H3;1H

InChIKey

ADBDFGZYGJGDNJ-UHFFFAOYSA-N

LogP

0.9708999999999999

Topological Polar Surface Area

38.33 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

130

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

Methyl 4-piperidineacetate hydrochloride
Methyl 2-(piperidin-4-yl)acetate hydrochloride
Methyl (4-Piperidyl)acetate Hydrochloride
4-Piperidineaceticacid, methyl ester, hydrochloride (1:1)
methyl 2-piperidin-4-ylacetate,hydrochloride
Methyl piperidin-4-ylacetate hydrochloride
Piperidin-4-YL-Acetic Acid Methyl Ester Hydrochloride
(4-Piperidyl)Acetic Acid Methyl Ester Hydrochloride
Piperidin-4-ylacetic acid methyl ester hydrochloride
(4-Piperidyl)acetic Acid Methyl Ester Hydrochloride
4-Piperidine acetic acid methyl ester hydrochloride
methyl 2-(piperidin-4-yl)acetate hydrochloride

MDL Number

MFCD09261419

Customs Code

2933399090

FAQ

What are the physical and chemical properties of Methyl 4-piperidinylacetate hydrochloride (CAS: 81270-37-3)?

Methyl 4-piperidinylacetate hydrochloride is a crystalline compound with a molecular weight of approximately 199.7 g/mol. It has a low solubility in water but is soluble in organic solvents. The compound is mildly basic and can react with acidic compounds. It is stable under normal storage conditions but should be kept away from strong oxidizing agents.

How is Methyl 4-piperidinylacetate hydrochloride (CAS: 81270-37-3) typically synthesized?

Methyl 4-piperidinylacetate hydrochloride is typically synthesized by reacting piperidine with acetyl chloride in the presence of a suitable base like sodium bicarbonate. The reaction is conducted at room temperature and yields a mixture that is then hydrolyzed with hydrochloric acid to form the hydrochloride salt. The product is isolated by crystallization.

What industries use Methyl 4-piperidinylacetate hydrochloride (CAS: 81270-37-3)?

Methyl 4-piperidinylacetate hydrochloride finds applications in pharmaceuticals, particularly as an intermediate for the synthesis of certain drugs. It is also used in the synthesis of polymers and as a precursor in the development of sensors and semiconductors.

What precautions should be taken when handling Methyl 4-piperidinylacetate hydrochloride (CAS: 81270-37-3)?

When handling Methyl 4-piperidinylacetate hydrochloride, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be used in a well-ventilated area or under a fume hood. Spills should be cleaned up using appropriate absorbents, and the area should be properly ventilated. Always consult the Safety Data Sheet (SDS) for detailed safety information.