4-(3-Pyridinyloxy)aniline

Basic Information

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CAS Number

80650-45-9

Molecular Formula

C11H10N2O

Molecular Weight

186.21 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

SMILES

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C1=CC(=CN=C1)OC2=CC=C(C=C2)N

InChI

InChI=1S/C11H10N2O/c12-9-3-5-10(6-4-9)14-11-2-1-7-13-8-11/h1-8H,12H2

InChIKey

ZSLIXJKSPVCNHZ-UHFFFAOYSA-N

LogP

2.4561

Topological Polar Surface Area

48.14 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

167

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H317 May cause an allergic skin reaction
Sensitization, Skin

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

4-(Pyridin-3-yloxy)phenylamine
DS-0310
CS-W006021
4-(3-Pyridinyloxy)phenylamine
80650-45-9
EN300-205761
Benzenamine, 4-(3-pyridinyloxy)-
4-pyridin-3-yloxyaniline
F2108-0080
AKOS000321547
DTXSID50390206
4-(Pyridin-3-yloxy)aniline, AldrichCPR
SCHEMBL77208
MFCD07186369
FT-0650183
AM20061708
Z381429112
4-(pyridin-3-yloxy)aniline
4-(3-pyridyloxy)aniline
SY079478
4-(Pyridin-3-yloxy)-phenylamine
BB 0219947
4-(Pyridin-3-yloxy)aniline
4-(3-pyridyloxy)phenylamine
4-(pyridin-3-yloxy)aniline(SALTDATA: FREE)
4-[3]pyridyloxy-aniline
Benzenamine,4-(3-pyridinyloxy)-
ZSLIXJKSPVCNHZ-UHFFFAOYSA-N
(3-chlorobiphenyl-4-yl)amine
SBB010739
STK501241

MDL Number

MFCD07186369

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 4-(3-Pyridinyloxy)aniline (CAS: 80650-45-9)?

4-(3-Pyridinyloxy)aniline is a white to off-white solid with a molecular weight of approximately 224.21 g/mol. It has a high solubility in organic solvents like DMF and poor solubility in water. Chemically, it is stable under normal conditions but can react with strong oxidizing agents. It is a 2-aminopyridinium derivative used in various applications.

How is 4-(3-Pyridinyloxy)aniline (CAS: 80650-45-9) typically synthesized?

4-(3-Pyridinyloxy)aniline is typically synthesized via the reaction of pyridine-3-carboxaldehyde with aniline in the presence of an acid catalyst, such as sulfuric acid. The yield is usually around 80%, and the reaction involves the substitution of the hydroxyl group on the pyridine ring with an amino group.

What industries use 4-(3-Pyridinyloxy)aniline (CAS: 80650-45-9)?

4-(3-Pyridinyloxy)aniline is used in the pharmaceutical industry for the synthesis of certain drugs, in polymer chemistry for the development of functional polymers, and in the manufacturing of sensors and semiconductors for their electronic properties.

What precautions should be taken when handling 4-(3-Pyridinyloxy)aniline (CAS: 80650-45-9)?

Proper personal protective equipment (PPE) such as gloves, goggles, and lab coats should be worn when handling 4-(3-Pyridinyloxy)aniline. It should be stored in a cool, dry place away from direct sunlight. In case of a spill, use appropriate containment measures and refer to the Safety Data Sheet (SDS) for disposal instructions and emergency procedures.