3-Bromo-2,6-difluoropyridine

Basic Information

View in Editor

CAS Number

80392-79-6

Molecular Formula

C5H2BrF2N

Molecular Weight

193.98 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

SMILES

View in Editor

Fc1ccc(Br)c(F)n1

InChI

InChI=1S/C5H2BrF2N/c6-3-1-2-4(7)9-5(3)8/h1-2H

InChIKey

GLWVPTDEVHPILQ-UHFFFAOYSA-N

LogP

2.1223

Topological Polar Surface Area

12.89 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

101

Synonyms & References

English

3-Bromo-2,6-difluoropyridine
3-BROMO-2,5-DIFLUOROPYRIDINE
2,6-difluoro-5-bromopyridine
QC-6971
Pyridine, 3-bromo-2,6-difluoro-
2,6-Difluoro-3-bromopyridine
GLWVPTDEVHPILQ-UHFFFAOYSA-N
RP08364
AM62469
AK122818
AB0070676
ST24041826
3-bromo-2,6-difluoropyridine

MDL Number

MFCD11044274

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 3-Bromo-2,6-difluoropyridine (CAS: 80392-79-6)?

3-Bromo-2,6-difluoropyridine is a crystalline solid with a molecular weight of approximately 244.02 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and dichloromethane. The compound is moderately reactive and can undergo nucleophilic substitution reactions. It has a high melting point of around 180-182°C and a low boiling point of 222-224°C. It is also sensitive to moisture and heat.

How is 3-Bromo-2,6-difluoropyridine (CAS: 80392-79-6) typically synthesized?

3-Bromo-2,6-difluoropyridine is typically synthesized by bromination of 2,6-difluoropyridine using bromine in an appropriate solvent like acetic acid. The reaction is carried out under mild conditions to achieve good selectivity and yield. The use of a phase transfer catalyst can enhance the reaction efficiency. The product is isolated through recrystallization or column chromatography.

What industries use 3-Bromo-2,6-difluoropyridine (CAS: 80392-79-6)?

3-Bromo-2,6-difluoropyridine is used in the pharmaceutical industry for the synthesis of certain drugs. It is also utilized in the semiconductor industry as an intermediate for organic light-emitting diodes (OLEDs) and in the production of polymer materials for sensors and other electronic applications.

What precautions should be taken when handling 3-Bromo-2,6-difluoropyridine (CAS: 80392-79-6)?

3-Bromo-2,6-difluoropyridine should be handled with caution due to its potential reactivity. Proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat is essential. It should be stored in a dry, cool, and well-ventilated area. In the event of a spill, the area should be immediately flushed with water and the spill cleaned up using appropriate absorbents. Safety data sheets (SDS) should be consulted for detailed handling and emergency procedures.