3-Bromo-2,6-difluoropyridine(CAS: 80392-79-6)

3-Bromo-2,6-difluoropyridine is a crystalline solid with a molecular weight of approximately 244.02 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and dichloromethane. The compound is moderately reactive and can undergo nucleophilic substitution reactions. It has a high melting point of around 180-182°C and a low boiling point of 222-224°C. It is also sensitive to moisture and heat.

3-Bromo-2,6-difluoropyridine is typically synthesized by bromination of 2,6-difluoropyridine using bromine in an appropriate solvent like acetic acid. The reaction is carried out under mild conditions to achieve good selectivity and yield. The use of a phase transfer catalyst can enhance the reaction efficiency. The product is isolated through recrystallization or column chromatography.

3-Bromo-2,6-difluoropyridine is used in the pharmaceutical industry for the synthesis of certain drugs. It is also utilized in the semiconductor industry as an intermediate for organic light-emitting diodes (OLEDs) and in the production of polymer materials for sensors and other electronic applications.

3-Bromo-2,6-difluoropyridine should be handled with caution due to its potential reactivity. Proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat is essential. It should be stored in a dry, cool, and well-ventilated area. In the event of a spill, the area should be immediately flushed with water and the spill cleaned up using appropriate absorbents. Safety data sheets (SDS) should be consulted for detailed handling and emergency procedures.