Cefpodoxime Acid

Basic Information

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CAS Number

80210-62-4

Molecular Formula

C15H17N5O6S2

Molecular Weight

427.46 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

200-202°C

Solubility

Soluble in DMSO

SMILES

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COCC1=C(N2C(C(C2=O)NC(=O)C(=NOC)C3=CSC(=N3)N)SC1)C(=O)O

InChI

InChI=1S/C15H17N5O6S2/c1-25-3-6-4-27-13-9(12(22)20(13)10(6)14(23)24)18-11(21)8(19-26-2)7-5-28-15(16)17-7/h5,9,13H,3-4H2,1-2H3,(H2,16,17)(H,18,21)(H,23,24)/b19-8-/t9-,13-/m1/s1

InChIKey

WYUSVOMTXWRGEK-HBWVYFAYSA-N

LogP

-0.5391999999999986

Topological Polar Surface Area

156.43999999999997 Å²

Hydrogen Bond Donor/Acceptor

4 / 11

Complexity

744

Safety Information

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Sensitiveness

Light Sensitive

Synonyms & References

English

CHEMBL1672
DTXCID402765
EN300-22411570
(+)-(6R,7R)-7-(2-(2-AMINO-4-THIAZOLYL)GLYOXYLAMIDO)-3-(METHOXYMETHYL)-8-OXO-5-THIA-1-AZABICYCLO(4.2.0)OCT-2-ENE-2-CARBOXYLIC ACID, 7(SUP 2)-(Z)-(O-METHYLOXIME)
BDBM50292251
SR-01000872579-1
CEFPODOXIME [WHO-DD]
(6R,7R)-7-({(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(methyloxy)imino]acetyl}amino)-3-[(methyloxy)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Cefpodoxime [INN:BAN]
Cefpodoximum (Latin)
Cefpodoxime (INN)
CEFPODOXIME PROXETIL IMPURITY A [EP IMPURITY]
Epoxim
SR-01000872579
AKOS016008786
7beta-((2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido)-3-(methoxymethyl)-3,4-didehydrocepham-4-carboxylic acid
Cefpodoxima [Spanish]
CEFPODOXIME [INN]
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-(methoxymethyl)-8-oxo-, (6R-(6alpha,7beta(Z)))-
MS-27549
RU 51807
Epoxim (TN)
D07650
CEFPODOXIME [MI]
1ST12018
(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
(6R,7R)-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
(6R,7R)-7-(((2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl)amino)-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid
CHEBI:3504
MFCD00864906

MDL Number

MFCD00864906

FAQ

What are the physical and chemical properties of Cefpodoxime Acid (CAS: 80210-62-4)?

Cefpodoxime acid is a crystalline compound with a molecular weight of approximately 346.36 g/mol. It is slightly soluble in water and ethanol. Chemically, it is reactive towards basic conditions and can undergo hydrolysis. It is an important intermediate in the synthesis of cephalosporin antibiotics.

How is Cefpodoxime Acid (CAS: 80210-62-4) typically synthesized?

Cefpodoxime acid is typically synthesized via a multi-step process involving the reaction of 7-ACA (7-aminocephalosporanic acid) with 4-chlorobenzyl chloromethyl ketone, followed by acidification. This process requires careful control of pH and temperature to achieve high yield and selectivity.

What industries use Cefpodoxime Acid (CAS: 80210-62-4)?

Cefpodoxime acid is primarily used in the pharmaceutical industry as an intermediate for the synthesis of cefpodoxime, a broad-spectrum antibiotic. It has less application in other industries like polymers, sensors, and semiconductors due to its specialized use in pharmaceuticals.

What precautions should be taken when handling Cefpodoxime Acid (CAS: 80210-62-4)?

When handling cefpodoxime acid, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, protective goggles, and lab coat. It should be stored in a dry, cool place away from direct sunlight and heat. In case of a spill, use appropriate safety measures and refer to the Safety Data Sheet (SDS) for detailed instructions.