3-Chloro-5-(trifluoromethyl)-2-pyridinecarbonitrile | CAS No. 80194-70-3
3-Chloro-5-(trifluoromethyl)-2-pyridinecarbonitrile
Basic Information
CAS Number
80194-70-3
Molecular Formula
C7H2ClF3N2
Molecular Weight
206.55 g/mol
AD
Chemical Classification
Basic Physical Properties
Boiling Point
250.4°C at 760 mmHg
Safety Information
View Safety InformationHazard Statement
H302
Harmful if swallowed
Acute toxicity, oral
Acute toxicity, oral
H315
Causes skin irritation
Skin corrosion/irritation
Skin corrosion/irritation
H319
Causes serious eye irritation
Serious eye damage/eye irritation
Serious eye damage/eye irritation
H335
May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation
Hazard Class
Class IRRITANT
Class IRRITANT
Synonyms & References
English
- AC-25639
- 3-chloro-5-trifluoromethyl-pyridine-2-carbonitrile
- CS-W002657
- AMY12467
- 80194-70-3
- 10F-048
- 3-Chloro-5-(trifluoromethyl)picolinonitrile
- 3 -chloro-2-cyano-5-trifluoromethylpyridine
- 3-chloro-5-(trifluoromethyl)-2-pyridinecarbonitrile
- 3-Chloro-5-trifluoromethylpyridine-2-carbonitrile
- 3-CHLORO-2-CYANO-5-(TRIFLUOROMETHYL)PYRIDINE
- 2-CYANO-3-CHLORO-5-(TRIFLUOROMETHYL)-PYRIDINE
- AKOS005069177
- A864732
- 3-chloro-5-(trifluoromethyl)picohnonitrile
- 2-Cyano-3-chloro-5-trifluoromethylpyridine
- 3-chloro-5-(trifluoromethyl)pyridine-2-carbonitrile
- FT-0679909
- EN300-192012
- SCHEMBL720136
- SY018211
- Z1269126257
- MFCD00664066
- 2-pyridinecarbonitrile, 3-chloro-5-(trifluoromethyl)-
- DTXSID10363032
- 3-chloro-2-cyano-5-trifluoromethylpyridine
- 3-chloro-5-(trifluoromethyl) picolinonitrile
- AB06676
- 2-Cyano-3-chloro-5-(trifluoromethyl)pyridine
- 2-Cyano-3-chloro-5-(trifluoromethyl)-pyridine
- 2-cyano-3-chloro-5-trifluoromethylpyridine
MDL Number
MFCD00664066
Customs Code
2933399090
FAQ
What are the physical and chemical properties of 3-Chloro-5-(trifluoromethyl)-2-pyridinecarbonitrile (CAS: 80194-70-3)?
3-Chloro-5-(trifluoromethyl)-2-pyridinecarbonitrile (CAS: 80194-70-3) is a crystalline solid with a molecular weight of approximately 265.02 g/mol. It is slightly soluble in water but soluble in organic solvents like ethanol and acetonitrile. This compound is known for its stability and low reactivity under normal conditions. It is not highly reactive but can undergo nucleophilic substitution reactions under certain conditions.
How is 3-Chloro-5-(trifluoromethyl)-2-pyridinecarbonitrile (CAS: 80194-70-3) typically synthesized?
3-Chloro-5-(trifluoromethyl)-2-pyridinecarbonitrile (CAS: 80194-70-3) is typically synthesized via the reaction of a pyridine derivative with hydrogen cyanide in the presence of a Lewis acid catalyst, such as aluminum chloride. The reaction is conducted under anhydrous conditions to ensure high selectivity and yield.
What industries use 3-Chloro-5-(trifluoromethyl)-2-pyridinecarbonitrile (CAS: 80194-70-3)?
3-Chloro-5-(trifluoromethyl)-2-pyridinecarbonitrile (CAS: 80194-70-3) is used in the pharmaceutical industry for the synthesis of certain drugs, particularly in the development of antiviral and antibacterial agents. It is also utilized in the polymer industry for additive formulations, and in the electronics sector for the production of semiconductors and sensors.
What precautions should be taken when handling 3-Chloro-5-(trifluoromethyl)-2-pyridinecarbonitrile (CAS: 80194-70-3)?
When handling 3-Chloro-5-(trifluoromethyl)-2-pyridinecarbonitrile (CAS: 80194-70-3), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be stored in a well-ventilated area and handled in a fume hood. Spills should be cleaned up immediately with appropriate absorbents, and the Material Safety Data Sheet (MSDS) should be consulted for detailed emergency procedures and safe handling instructions.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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