3-Chloro-5-(trifluoromethyl)-2-pyridinecarbonitrile(CAS: 80194-70-3)

3-Chloro-5-(trifluoromethyl)-2-pyridinecarbonitrile (CAS: 80194-70-3) is a crystalline solid with a molecular weight of approximately 265.02 g/mol. It is slightly soluble in water but soluble in organic solvents like ethanol and acetonitrile. This compound is known for its stability and low reactivity under normal conditions. It is not highly reactive but can undergo nucleophilic substitution reactions under certain conditions.

3-Chloro-5-(trifluoromethyl)-2-pyridinecarbonitrile (CAS: 80194-70-3) is typically synthesized via the reaction of a pyridine derivative with hydrogen cyanide in the presence of a Lewis acid catalyst, such as aluminum chloride. The reaction is conducted under anhydrous conditions to ensure high selectivity and yield.

3-Chloro-5-(trifluoromethyl)-2-pyridinecarbonitrile (CAS: 80194-70-3) is used in the pharmaceutical industry for the synthesis of certain drugs, particularly in the development of antiviral and antibacterial agents. It is also utilized in the polymer industry for additive formulations, and in the electronics sector for the production of semiconductors and sensors.

When handling 3-Chloro-5-(trifluoromethyl)-2-pyridinecarbonitrile (CAS: 80194-70-3), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be stored in a well-ventilated area and handled in a fume hood. Spills should be cleaned up immediately with appropriate absorbents, and the Material Safety Data Sheet (MSDS) should be consulted for detailed emergency procedures and safe handling instructions.