Epinastine Hydrochloride

Basic Information

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CAS Number

80012-44-8

Molecular Formula

C16H16ClN3

Molecular Weight

285.77 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

270ºC

SMILES

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C1C2C3=CC=CC=C3CC4=CC=CC=C4N2C(=N1)N.Cl

InChI

InChI=1S/C16H15N3.ClH/c17-16-18-10-15-13-7-3-1-5-11(13)9-12-6-2-4-8-14(12)19(15)16;/h1-8,15H,9-10H2,(H2,17,18);1H

InChIKey

VKXSGUIOOQPGAF-UHFFFAOYSA-N

LogP

2.8886000000000007

Topological Polar Surface Area

41.62 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

378

Synonyms & References

English

Epinastine hydrochloride [JAN]
1H-Dibenz[c,f]imidazo[1,5-a]azepin-3-amine, 9,13b-dihydro-,hydrochloride
EPINASTINE HYDROCHLORIDE (MART.)
WAL-801CL HCl
IH-Dibenz(c,f)imidazo(1,5-a)azepin-3-amine, 9,13b-dihydro-, monohydrochloride
3-Amino-9,13b-dihydro-1H-dibenz(c,f)imidazo(1,5-a)azepine monohydrochloride
F17420
Epinastine hydrochloride
EX-A1004
AC-1491
Epinastine hydrochloride, >=98% (HPLC), solid
Epinastinehydrochloride
KS-1159
EPINASTINE HYDROCHLORIDE (USP-RS)
(13bRS)-9,13b-Dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepin-3-amine hydrochloride; 1H-Dibenz[c,f]imidazo[1,5-a]azepin-3-amine, 9,13b-dihydro-, monohydrochloride (9CI); Alesion; Elestat; Epinastine hydrochloride; WAL 801CL
Q27122286
Elestat
Tox21_112263
CAS-108929-04-0
Elestat (TN)
VKXSGUIOOQPGAF-UHFFFAOYSA-N
BCP12119
EPINASTINE HYDROCHLORIDE [USP-RS]
D01713
WAL-802-CL
SCHEMBL122749
108929-04-0
9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepin-3-amine hydrochloride
Flurinol
CS-0013220
2,4-diazatetracyclo[12.4.0.02,6.07,12]octadeca-1(18),3,7,9,11,14,16-heptaen-3-amine;hydrochloride

FAQ

What are the physical and chemical properties of epinastine hydrochloride (CAS: 80012-44-8)?

Epinastine hydrochloride is a white to off-white crystalline powder with a molecular weight of approximately 327.81 g/mol. It has a pKa of 1.7 and is soluble in water (2.48 g/100 mL at 25°C). Chemically, it is stable under normal conditions but can hydrolyze in basic solutions. It is reactive to acids and bases.

How is epinastine hydrochloride (CAS: 80012-44-8) typically synthesized?

Epinastine hydrochloride can be synthesized from epinastine by reacting it with hydrochloric acid. The reaction is performed in a suitable solvent like methanol or ethanol. The process is carried out under mild conditions and involves careful monitoring to achieve high selectivity and yield.

What industries use epinastine hydrochloride (CAS: 80012-44-8)?

Epinastine hydrochloride is primarily used in the pharmaceutical industry for its antihistaminic properties. It is also used in some light industries for its chemical reactivity. Its applications include the formulation of allergy medications and as a research compound for drug development.

What precautions should be taken when handling epinastine hydrochloride (CAS: 80012-44-8)?

When handling epinastine hydrochloride, wear appropriate personal protective equipment (PPE), including gloves and safety goggles. Store it in a cool, dry place away from direct sunlight. Use in a well-ventilated area or a fume hood. Follow safety data sheet (SDS) guidelines for disposal and spill cleanup. Ensure proper ventilation and avoid inhaling dust or aerosols.