Methyl 5-amino-6-bromo-2-pyridinecarboxylate

Basic Information

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CAS Number

797060-52-7

Molecular Formula

C7H7BrN2O2

Molecular Weight

231.05 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

SMILES

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COC(=O)c1ccc(N)c(Br)n1

InChI

InChI=1S/C7H7BrN2O2/c1-12-7(11)5-3-2-4(9)6(8)10-5/h2-3H,9H2,1H3

InChIKey

BQRNYEXDPHWQLV-UHFFFAOYSA-N

LogP

1.2128999999999999

Topological Polar Surface Area

65.21000000000001 Å²

Hydrogen Bond Donor/Acceptor

2 / 4

Synonyms & References

English

methyl 5-amino-6-bromopicolinate
Methyl 5-amino-6-bromo-2-pyridinecarboxylate
methyl 5-amino-6-bromo-pyridine-2-carboxylate

MDL Number

MFCD16036645

FAQ

What are the physical and chemical properties of Methyl 5-amino-6-bromo-2-pyridinecarboxylate (CAS: 797060-52-7)?

Methyl 5-amino-6-bromo-2-pyridinecarboxylate (CAS: 797060-52-7) is a crystalline solid with a molecular weight of approximately 255.04 g/mol. It has a low solubility in water but is soluble in organic solvents like ethanol and acetone. Chemically, it is moderately reactive, particularly towards nucleophiles and reducing agents. It is stable under normal conditions but should be stored away from reducing agents and strong bases to prevent unwanted side reactions.

How is Methyl 5-amino-6-bromo-2-pyridinecarboxylate (CAS: 797060-52-7) typically synthesized?

Methyl 5-amino-6-bromo-2-pyridinecarboxylate is typically synthesized via a nucleophilic substitution reaction where a bromo-2-pyridinecarboxylic acid derivative reacts with methylamine. The synthesis involves the use of a base like sodium hydride to activate the carboxylic acid, followed by the addition of methylamine. The yield is typically around 70-80%, and the reaction is carried out under anhydrous conditions to avoid side reactions.

What industries use Methyl 5-amino-6-bromo-2-pyridinecarboxylate (CAS: 797060-52-7)?

Methyl 5-amino-6-bromo-2-pyridinecarboxylate (CAS: 797060-52-7) is used in the pharmaceutical industry for the synthesis of certain drug molecules. It is also relevant in the polymer industry for the modification of polymer properties and in the sensor industry for developing specific chemical sensors. Additionally, it has applications in the semiconductor industry for certain analytical and processing purposes.

What precautions should be taken when handling Methyl 5-amino-6-bromo-2-pyridinecarboxylate (CAS: 797060-52-7)?

When handling Methyl 5-amino-6-bromo-2-pyridinecarboxylate (CAS: 797060-52-7), appropriate personal protective equipment (PPE) should be worn, including gloves and safety glasses. It should be stored in a cool, dry place away from reducing agents. Fume hoods should be used during synthesis and handling to avoid inhalation. In case of a spill, it is important to use a spill kit and follow local safety guidelines. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.