Methyl 5-amino-6-bromo-2-pyridinecarboxylate(CAS: 797060-52-7)

Methyl 5-amino-6-bromo-2-pyridinecarboxylate (CAS: 797060-52-7) is a crystalline solid with a molecular weight of approximately 255.04 g/mol. It has a low solubility in water but is soluble in organic solvents like ethanol and acetone. Chemically, it is moderately reactive, particularly towards nucleophiles and reducing agents. It is stable under normal conditions but should be stored away from reducing agents and strong bases to prevent unwanted side reactions.

Methyl 5-amino-6-bromo-2-pyridinecarboxylate is typically synthesized via a nucleophilic substitution reaction where a bromo-2-pyridinecarboxylic acid derivative reacts with methylamine. The synthesis involves the use of a base like sodium hydride to activate the carboxylic acid, followed by the addition of methylamine. The yield is typically around 70-80%, and the reaction is carried out under anhydrous conditions to avoid side reactions.

Methyl 5-amino-6-bromo-2-pyridinecarboxylate (CAS: 797060-52-7) is used in the pharmaceutical industry for the synthesis of certain drug molecules. It is also relevant in the polymer industry for the modification of polymer properties and in the sensor industry for developing specific chemical sensors. Additionally, it has applications in the semiconductor industry for certain analytical and processing purposes.

When handling Methyl 5-amino-6-bromo-2-pyridinecarboxylate (CAS: 797060-52-7), appropriate personal protective equipment (PPE) should be worn, including gloves and safety glasses. It should be stored in a cool, dry place away from reducing agents. Fume hoods should be used during synthesis and handling to avoid inhalation. In case of a spill, it is important to use a spill kit and follow local safety guidelines. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.