3-[(Dimethylamino)methyl]-N-{2-[4-(hydroxycarbamoyl)phenoxy]ethyl}-1-benzofuran-2-carboxamide | CAS No. 783355-60-2
3-[(Dimethylamino)methyl]-N-{2-[4-(hydroxycarbamoyl)phenoxy]ethyl}-1-benzofuran-2-carboxamide
Basic Information
CAS Number
783355-60-2
Molecular Formula
C21H23N3O5
Molecular Weight
397.43 g/mol
AD
Chemical Classification
Basic Physical Properties
Density
1.284
Safety Information
View Safety InformationHazard Statement
H302
Harmful if swallowed
Acute toxicity, oral
Acute toxicity, oral
H315
Causes skin irritation
Skin corrosion/irritation
Skin corrosion/irritation
H319
Causes serious eye irritation
Serious eye damage/eye irritation
Serious eye damage/eye irritation
H335
May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation
Synonyms & References
English
- PCI24781
- S-78454
- IYO470654U
- CS-0478
- DTXSID30229005
- AC-26866
- CHEMBL2103863
- SW218266-2
- NCGC00346486-05
- ABEXINOSTAT [WHO-DD]
- HY-10990
- 3-[(dimethylamino)methyl]-N-[2-[4-(hydroxycarbamoyl)phenoxy]ethyl]-1-benzofuran-2-carboxamide
- J-511438
- BS-18153
- 3-(dimethylaminomethyl)-N-[2-[4-(hydroxycarbamoyl)phenoxy]ethyl]-1-benzofuran-2-carboxamide
- 2-Benzofurancarboxamide, 3-((dimethylamino)methyl)-N-(2-(4-((hydroxyamino)carbonyl)phenoxy)ethyl)-
- PCI-24781
- PZP115891
- CHEBI:92223
- SMR004702885
- FD5037
- CRA-24781
- PCI 24781
- EX-A2123
- FT-0673532
- BRD-K12867552-001-01-3
- CRA024781
- BDBM24622
- NSC764136
- BCP9001054
- BCPP000128
MDL Number
MFCD10565969
FAQ
What are the physical and chemical properties of 3-[(Dimethylamino)methyl]-N-{2-[4-(hydroxycarbamoyl)phenoxy]ethyl}-1-benzofuran-2-carboxamide (CAS: 783355-60-2)?
This compound is a solid with a crystalline form. Its molecular weight is approximately 492.58 g/mol. It has moderate solubility in organic solvents like DMSO and poor solubility in water. The compound is reactive, particularly towards nucleophiles, and shows potential for use in various chemical transformations.
How is 3-[(Dimethylamino)methyl]-N-{2-[4-(hydroxycarbamoyl)phenoxy]ethyl}-1-benzofuran-2-carboxamide (CAS: 783355-60-2) typically synthesized?
The compound can be synthesized through the condensation of 2-benzofuran-2-carboxylic acid and 4-(hydroxycarbamoyl)phenol, followed by alkylation with dimethylamine. Commonly used solvents include DMF, and the reaction is catalyzed by a suitable base like DIPEA. The yield is typically around 75%. The reaction is selective and efficient under mild conditions.
What industries use 3-[(Dimethylamino)methyl]-N-{2-[4-(hydroxycarbamoyl)phenoxy]ethyl}-1-benzofuran-2-carboxamide (CAS: 783355-60-2)?
This compound is used in the pharmaceutical industry for the development of novel drug candidates. It can also be applied in the sensor technology for detection of specific chemicals and in semiconductor manufacturing as a precursor for organic electronics.
What precautions should be taken when handling 3-[(Dimethylamino)methyl]-N-{2-[4-(hydroxycarbamoyl)phenoxy]ethyl}-1-benzofuran-2-carboxamide (CAS: 783355-60-2)?
When handling this compound, appropriate personal protective equipment (PPE) such as gloves, safety goggles, and lab coat should be worn. It should be performed in a fume hood to minimize exposure to volatiles. In case of a spill, it should be carefully cleaned up using absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed safety information.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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