4-(2-Piperazinyl)phenol

Basic Information

View in Editor

CAS Number

783251-37-6

Molecular Formula

C10H14N2O

Molecular Weight

178.24 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

204°C

SMILES

View in Editor

C1CNC(CN1)C2=CC=C(C=C2)O

InChI

InChI=1S/C10H14N2O/c13-9-3-1-8(2-4-9)10-7-11-5-6-12-10/h1-4,10-13H,5-7H2

InChIKey

SASIFHOHGBPKMK-UHFFFAOYSA-N

LogP

0.6260999999999999

Topological Polar Surface Area

44.29 Å²

Hydrogen Bond Donor/Acceptor

3 / 3

Complexity

155

Safety Information

View Safety Information

Hazard Class

Class 8 Class 8

Sensitiveness

Air Sensitive

Synonyms & References

English

4-PIPERAZIN-2-YL-PHENOL
MFCD05864684
FT-0659673
4-piperazin-2-ylphenol
J-515956
A839394
4-(2-piperazinyl)phenol
AKOS005254268
4-(piperazin-2-yl)phenol
ACIDRED183
4-piperazin-2-yl-phenol, AldrichCPR
DTXSID30587672
783251-37-6
SCHEMBL6131967
FS-2838
4-(Piperazin-2-yl)phenol
4-Piperazin-2-yl-phenol
4-Piperazine-2-Yl-Phenol
Phenol,4-(2-piperazinyl)

MDL Number

MFCD05864684

Customs Code

2933599090

FAQ

What are the physical and chemical properties of 4-(2-Piperazinyl)phenol (CAS: 783251-37-6)?

4-(2-Piperazinyl)phenol (CAS: 783251-37-6) is a crystalline solid with a molecular weight of approximately 226.28 g/mol. It has a solubility of about 2.4 g/L in water and is moderately soluble in common organic solvents. The compound is reactive towards acidic conditions and can undergo substitution reactions. It has a pKa of around 10.5.

How is 4-(2-Piperazinyl)phenol (CAS: 783251-37-6) typically synthesized?

4-(2-Piperazinyl)phenol (CAS: 783251-37-6) is synthesized via a multistep process involving the reaction of p-hydroxybenzaldehyde with piperazine. The key steps include condensation, rearrangement, and reduction, which yield the desired phenol with good selectivity and yield. Common catalysts include sodium hydroxide and other base catalysts.

What industries use 4-(2-Piperazinyl)phenol (CAS: 783251-37-6)?

4-(2-Piperazinyl)phenol (CAS: 783251-37-6) is primarily used in the pharmaceutical industry as a precursor for developing novel drugs. It also finds applications in the polymer industry for modifying material properties, and in the semiconductor industry for functionalizing surfaces. Additionally, it has potential uses in sensors for detecting specific chemical compounds.

What precautions should be taken when handling 4-(2-Piperazinyl)phenol (CAS: 783251-37-6)?

When handling 4-(2-Piperazinyl)phenol (CAS: 783251-37-6), appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. The compound should be handled in a well-ventilated area or a fume hood to prevent inhalation. In case of a spill, it should be cleaned up immediately using absorbent materials. Always refer to the safety data sheet (SDS) for detailed handling and disposal instructions.