4-(2-Piperazinyl)phenol(CAS: 783251-37-6)

4-(2-Piperazinyl)phenol (CAS: 783251-37-6) is a crystalline solid with a molecular weight of approximately 226.28 g/mol. It has a solubility of about 2.4 g/L in water and is moderately soluble in common organic solvents. The compound is reactive towards acidic conditions and can undergo substitution reactions. It has a pKa of around 10.5.

4-(2-Piperazinyl)phenol (CAS: 783251-37-6) is synthesized via a multistep process involving the reaction of p-hydroxybenzaldehyde with piperazine. The key steps include condensation, rearrangement, and reduction, which yield the desired phenol with good selectivity and yield. Common catalysts include sodium hydroxide and other base catalysts.

4-(2-Piperazinyl)phenol (CAS: 783251-37-6) is primarily used in the pharmaceutical industry as a precursor for developing novel drugs. It also finds applications in the polymer industry for modifying material properties, and in the semiconductor industry for functionalizing surfaces. Additionally, it has potential uses in sensors for detecting specific chemical compounds.

When handling 4-(2-Piperazinyl)phenol (CAS: 783251-37-6), appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. The compound should be handled in a well-ventilated area or a fume hood to prevent inhalation. In case of a spill, it should be cleaned up immediately using absorbent materials. Always refer to the safety data sheet (SDS) for detailed handling and disposal instructions.