(2R)-2-Phenylpropanoic acid

Basic Information

View in Editor

CAS Number

7782-26-5

Molecular Formula

C9H10O2

Molecular Weight

150.18 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Physical State

Colorless to Yellow Solid

Melting Point

29-30 °C

Boiling Point

115 °C/1 mmHg

Density

1.1 g/mL at 25 °C

Refractive Index

n20/D 1.523(lit.)

Specific Rotation

-75 º (c=3,CHCl3)

SMILES

View in Editor

CC(C1=CC=CC=C1)C(=O)O

InChI

InChI=1S/C9H10O2/c1-7(9(10)11)8-5-3-2-4-6-8/h2-7H,1H3,(H,10,11)/t7-/m1/s1

InChIKey

YPGCWEMNNLXISK-SSDOTTSWSA-N

LogP

1.8747

Topological Polar Surface Area

37.3 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

137

Safety Information

View Safety Information

GHS Hazard Pictograms

H315

H319

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

Benzeneacetic acid, .alpha.-methyl-, (R)-
(R)-.ALPHA.-METHYLPHENYLACETIC ACID
(R)-2-phenylpropionic acid
R-2-PHENYL-PROPRIONIC ACID
(R)-(-)-Hydratropic acid, (R)-HTA
AKOS005146367
(-)-2-PHENYLPROPANOIC ACID
HYDRATROPIC ACID, (R)-(-)-
2-PHENYLPROPIONIC ACID, (-)-
CHEBI:43035
Benzeneacetic acid, alpha-methyl-, (R)-
3YF5O2136L
AM20060730
UNII-3YF5O2136L
(R)-.ALPHA.-METHYLBENZENEACETIC ACID
(-)-Hydratropasaeure
(R)-2-phenylpropanoic acid
(R)-2-Phenyl-propionic acid
7782-26-5
r-(-)-2-phenylpropionic acid
(R)-hydratropic acid
(R)-(-)-2-Phenylpropionic acid
SCHEMBL66842
P1219
(-)-2-phenylpropionic acid
L-PPA
(2R)-2-phenylpropanoic acid
AS-17271
A9829
(R)-alpha-methylbenzeneacetic acid
(R)-(-)-2-Phenylpropionic acid, 97%

MDL Number

MFCD00063140

FAQ

What are the physical and chemical properties of (2R)-2-Phenylpropanoic acid (CAS: 7782-26-5)?

(2R)-2-Phenylpropanoic acid is a white crystalline solid with a molecular weight of approximately 146.21 g/mol. It has a pKa of about 3.5 and is slightly soluble in water but more soluble in organic solvents. It is reactive towards basic conditions and can undergo various esterification and amidation reactions.

How is (2R)-2-Phenylpropanoic acid (CAS: 7782-26-5) typically synthesized?

(2R)-2-Phenylpropanoic acid can be synthesized via a Grignard reaction of phenylmagnesium bromide with propanoyl chloride, followed by hydrolysis to yield the carboxylic acid. This method provides good yield and selectivity, and appropriate catalysts can enhance the reaction efficiency.

What industries use (2R)-2-Phenylpropanoic acid (CAS: 7782-26-5)?

(2R)-2-Phenylpropanoic acid is used in the pharmaceutical industry as a precursor for several drug molecules, in polymer synthesis for functional polymers, and in the production of organic sensors and semiconductors due to its unique chemical properties and functionality.

What precautions should be taken when handling (2R)-2-Phenylpropanoic acid (CAS: 7782-26-5)?

When handling (2R)-2-Phenylpropanoic acid, wear appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coat. Store in a cool, dry place away from direct sunlight and heat sources. Use a fume hood during operations to avoid inhalation. In case of spill, immediately clean up using appropriate absorbents and consult the Safety Data Sheet (SDS) for further instructions.